Glioblastoma Stem-like Cells-biology and Therapeutic Implications

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2011 Jul 29

PMID 21796273

Citations 22

Authors

Demirkan B Gursel

Benjamin J Shin

Jan-Karl Burkhardt

Kartik Kesavabhotla

Cody D Schlaff

John A Boockvar

Affiliations

Soon will be listed here.

Abstract

The cancer stem-cell hypothesis proposes that malignant tumors are likely to encompass a cellular hierarchy that parallels normal tissue and may be responsible for the maintenance and recurrence of glioblastoma multiforme (GBM) in patients. The purpose of this manuscript is to review methods for optimizing the derivation and culturing of stem-like cells also known as tumor stem cells (TSCs) from patient-derived GBM tissue samples. The hallmarks of TSCs are that they must be able to self-renew and retain tumorigenicity. The isolation, optimization and derivation of TSCs as outlined in this review, will be important in understanding biology and therapeutic applications related to these cells.

Citing Articles

Alteration of Mesenchymal Stem Cells Isolated from Glioblastoma Multiforme under the Influence of Photodynamic Treatment.

Tumangelova-Yuzeir K, Minkin K, Angelov I, Ivanova-Todorova E, Kurteva E, Vasilev G Curr Issues Mol Biol. 2023; 45(3):2580-2596.

PMID: 36975539 PMC: 10047864. DOI: 10.3390/cimb45030169.

Alterations in Molecular Profiles Affecting Glioblastoma Resistance to Radiochemotherapy: Where Does the Good Go?.

Vilar J, Christmann M, Tomicic M Cancers (Basel). 2022; 14(10).

PMID: 35626024 PMC: 9139489. DOI: 10.3390/cancers14102416.

MEOX2 Transcription Factor Is Involved in Survival and Adhesion of Glioma Stem-like Cells.

Tachon G, Masliantsev K, Rivet P, Desette A, Milin S, Gueret E Cancers (Basel). 2021; 13(23).

PMID: 34885053 PMC: 8672280. DOI: 10.3390/cancers13235943.

The E3 Ubiquitin Ligase NEDD4-1 Mediates Temozolomide-Resistant Glioblastoma through PTEN Attenuation and Redox Imbalance in Nrf2-HO-1 Axis.

Chuang H, Hsu L, Pan C, Pikatan N, Yadav V, Fong I Int J Mol Sci. 2021; 22(19).

PMID: 34638586 PMC: 8549703. DOI: 10.3390/ijms221910247.

Combined Treatment with Acalabrutinib and Rapamycin Inhibits Glioma Stem Cells and Promotes Vascular Normalization by Downregulating BTK/mTOR/VEGF Signaling.

Su Y, Bamodu O, Su I, Pikatan N, Fong I, Lee W Pharmaceuticals (Basel). 2021; 14(9).

PMID: 34577576 PMC: 8464793. DOI: 10.3390/ph14090876.

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