Kinesin Molecular Motor Eg5 Functions During Polypeptide Synthesis

Overview

Journal Mol Biol Cell

Specialties Cell Biology
Molecular Biology

Date 2011 Jul 29

PMID 21795388

Citations 26

Authors

Kristen M Bartoli

Jelena Jakovljevic

John L Woolford Jr

William S Saunders

Affiliations

Soon will be listed here.

Abstract

The kinesin-related molecular motor Eg5 plays roles in cell division, promoting spindle assembly. We show that during interphase Eg5 is associated with ribosomes and is required for optimal nascent polypeptide synthesis. When Eg5 was inhibited, ribosomes no longer bound to microtubules in vitro, ribosome transit rates slowed, and polysomes accumulated in intact cells, suggesting defects in elongation or termination during polypeptide synthesis. These results demonstrate that the molecular motor Eg5 associates with ribosomes and enhances the efficiency of translation.

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