Primary Mediastinal DLBCL: Evolving Biologic Understanding and Therapeutic Strategies

Overview

Journal Curr Oncol Rep

Publisher Current Science

Specialty Oncology

Date 2011 Jul 27

PMID 21789543

Citations 7

Authors

Pier Luigi Zinzani

Pier Paolo Piccaluga

Affiliations

Soon will be listed here.

Abstract

Primary mediastinal diffuse large B-cell lymphoma is a quite rare clinicopathologic entity. Molecular analysis shows it to be distinct from other types of diffuse large B-cell lymphoma, and some retrospective analyses suggests that it may respond better to third-generation chemotherapy regimens than to the more commonly used CHOP. The addition of rituximab could reduce these differences; the role of consolidation with local radiotherapy, which is often used to treat residual mediastinal masses, remains. The real role of FDG-PET scanning requires prospective studies, and it is hoped that this may allow the de-escalation of radiation therapy accordingly to yield reliable prognostic information.

Citing Articles

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