Environmental Exposures and Rheumatoid Arthritis Risk

Overview

Journal Curr Rheumatol Rep

Publisher Current Science

Specialty Rheumatology

Date 2011 Jul 26

PMID 21785978

Citations 37

Authors

Ryan A Hoovestol

Ted R Mikuls

Affiliations

Soon will be listed here.

Abstract

In addition to rapidly burgeoning data regarding novel genetic risk factors, a growing list of environmental exposures have been implicated in rheumatoid arthritis (RA) susceptibility. Cigarette smoking is chief among the many environmental exposures implicated in disease risk, accounting for approximately one in six new cases of RA, with recent results underscoring the central importance of select gene-smoking interactions in RA development. In this review, we examine data linking several environmental exposures with RA risk, including cigarette smoking, other air pollutants and occupational exposures, reproductive/hormonal influences, alcohol consumption, select infections leading to periodontal disease, and dietary factors. Where applicable, we review the current understanding of biologic mechanisms linking these environmental factors to disease risk.

Citing Articles

Causal Relationships Between Environmental Exposures, Iron Metabolism, Hematuria Markers, and Rheumatoid Arthritis: An Investigation Using Mendelian Randomization.

Wang C, Xie W, Wang C, Zhu Y, Zhong D Biomedicines. 2025; 13(2).

PMID: 40002926 PMC: 11852645. DOI: 10.3390/biomedicines13020513.

Association of Interleukin 23 Receptor Polymorphisms with Predisposition to Rheumatoid Arthritis: An Updated Meta and Trial Sequential Analysis.

Sarangi S, Barik D, Nahak S, Panda A Biochem Genet. 2024; 62(5):4067-4086.

PMID: 38270697 DOI: 10.1007/s10528-023-10644-x.

Caffeine, Coffee, Tea and Risk of Rheumatoid Arthritis: Systematic Review and Dose-Response Meta-analysis of Prospective Cohort Studies.

Asoudeh F, Dashti F, Jayedi A, Hemmati A, Fadel A, Mohammadi H Front Nutr. 2022; 9:822557.

PMID: 35223954 PMC: 8866764. DOI: 10.3389/fnut.2022.822557.

Association of rheumatoid arthritis and its severity with human leukocytic antigen-DRB1 alleles in Kurdish region in North of Iraq.

Albarzinji N, Ismael S, Albustany D BMC Rheumatol. 2022; 6(1):4.

PMID: 35016727 PMC: 8753826. DOI: 10.1186/s41927-021-00229-9.

Airway Disease in Rheumatoid Arthritis.

Matson S, Demoruelle M, Castro M Ann Am Thorac Soc. 2021; 19(3):343-352.

PMID: 34929135 PMC: 9820913. DOI: 10.1513/AnnalsATS.202107-876CME.

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