Alpha 2.0
Login Register
» Articles » PMID: 21785427

The Second Phytophthora Mating Hormone Defines Interspecies Biosynthetic Crosstalk

Overview
Journal Nat Chem Biol
Specialties Biochemistry
Biology
Chemistry
Date 2011 Jul 26
PMID 21785427
Citations 12
Authors
Makoto Ojika
Shylaja D Molli
Harumi Kanazawa
Arata Yajima
Kou Toda
Tomoo Nukada
Haimeng Mao
Ryo Murata
Tomoyo Asano
Jianhua Qi
Youji Sakagami
Affiliations
Soon will be listed here.
Abstract

The heterothallic species of the agricultural pest Phytophthora use mating hormones α1 and α2 to regulate their sexual reproduction. Here we describe the absolute stereostructure of the second mating hormone α2 as defined by spectroscopic analysis and total synthesis. We have uncovered not only the interspecies universality of α hormones but also the pathway by which α2 is biosynthesized from phytol by A2-mating type strains and metabolized to α1 by A1 strains.

Citing Articles

Histone (de)acetylation in epigenetic regulation of Phytophthora pathobiology.

Guan Y, Gajewska J, Floryszak-Wieczorek J, Tanwar U, Sobieszczuk-Nowicka E, Arasimowicz-Jelonek M Mol Plant Pathol. 2024; 25(7):e13497.

PMID: 39034655 PMC: 11261156. DOI: 10.1111/mpp.13497.

A novel and ubiquitous miRNA-involved regulatory module ensures precise phosphorylation of RNA polymerase II and proper transcription.

Wang Z, Zhong S, Zhang S, Zhang B, Zheng Y, Sun Y PLoS Pathog. 2024; 20(4):e1012138.

PMID: 38640110 PMC: 11062530. DOI: 10.1371/journal.ppat.1012138.

Validation of reference gene stability for normalization of RT-qPCR in Phytophthora capsici Leonian during its interaction with Piper nigrum L.

Vijayakumar S, Sakuntala M Sci Rep. 2024; 14(1):7331.

PMID: 38538851 PMC: 10973370. DOI: 10.1038/s41598-024-58139-y.

Enhancing chemical and biological diversity by co-cultivation.

Selegato D, Castro-Gamboa I Front Microbiol. 2023; 14:1117559.

PMID: 36819067 PMC: 9928954. DOI: 10.3389/fmicb.2023.1117559.

Identification of the First Oomycete Mating-type Locus Sequence in the Grapevine Downy Mildew Pathogen, Plasmopara viticola.

Dussert Y, Legrand L, Mazet I, Couture C, Piron M, Serre R Curr Biol. 2020; 30(20):3897-3907.e4.

PMID: 32795448 PMC: 7116238. DOI: 10.1016/j.cub.2020.07.057.

References
1.
Fry W . Phytophthora infestans: the plant (and R gene) destroyer. Mol Plant Pathol. 2008; 9(3):385-402. PMC: 6640234. DOI: 10.1111/j.1364-3703.2007.00465.x. View
2.
Tyler B, Tripathy S, Zhang X, Dehal P, Jiang R, Aerts A . Phytophthora genome sequences uncover evolutionary origins and mechanisms of pathogenesis. Science. 2006; 313(5791):1261-6. DOI: 10.1126/science.1128796. View
3.
Bajpai R, Yang F, Curran D . On the structure of the Phytophthora α1 mating hormone: synthesis and comparison of four candidate stereoisomers. Tetrahedron Lett. 2008; 48(45):7965-7968. PMC: 2083561. DOI: 10.1016/j.tetlet.2007.09.054. View
4.
Haas B, Kamoun S, Zody M, Jiang R, Handsaker R, Cano L . Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans. Nature. 2009; 461(7262):393-8. DOI: 10.1038/nature08358. View
5.
Judelson H, Blanco F . The spores of Phytophthora: weapons of the plant destroyer. Nat Rev Microbiol. 2004; 3(1):47-58. DOI: 10.1038/nrmicro1064. View