Regulatory Functions of Protein Kinase C in Glomerular Mesangial Cells

Overview

Journal Klin Wochenschr

Specialty General Medicine

Date 1990 Nov 16

PMID 2177811

Citations 3

Authors

J Pfeilschifter

Affiliations

Soon will be listed here.

Abstract

Protein kinase C is a family of isozymes that are activated by hormone-stimulated phosphoinositide hydrolysis and participate in the signalling process by phosphorylating certain target proteins. In glomerular mesangial cells protein kinase C fulfills two major functions: it contributes to hormone-induced prostaglandin formation, and it acts as a negative feedback regulator of the inositol lipid signalling cascade. Furthermore, protein kinase C activates a phosphatidylcholine-degrading phospholipase D activity with as-yet-unknown cellular function.

Citing Articles

Simultaneous registration of Ca(2+) transients and volume changes in rat mesangial cells: Evaluation of the effects of protein kinase C down-regulation.

Ochsner M, Fleck T, Kernen P, Deranleau D, Pfeilschifter J J Fluoresc. 2013; 2(1):37-45.

PMID: 24243157 DOI: 10.1007/BF00866387.

Cellular and molecular pathomechanisms of diabetic nephropathy.

Thaiss F, Stahl R Clin Investig. 1993; 71(10):830-3.

PMID: 8305843 DOI: 10.1007/BF00190331.

The inflammatory function of renal glomerular mesangial cells and their interaction with the cellular immune system.

Radeke H, Resch K Clin Investig. 1992; 70(9):825-42.

PMID: 1450638 DOI: 10.1007/BF00180754.

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