Evaluating the Progenitor Cells of Ovarian Cancer: Analysis of Current Animal Models

Overview

Journal BMB Rep

Specialties Biochemistry
Molecular Biology

Date 2011 Jul 23

PMID 21777513

Citations 17

Authors

Shelby M King

Joanna E Burdette

Affiliations

Soon will be listed here.

Abstract

Serous ovarian cancer is one of the most lethal gynecological malignancies. Progress on effective diagnostics and therapeutics for this disease are hampered by ambiguity as to the cellular origins of this histotype of ovarian cancer, as well as limited suitable animal models to analyze early stages of disease. In this report, we will review current animal models with respect to the two proposed progenitor cells for serous ovarian cancer, the ovarian surface epithelium and the fallopian tube epithelium.

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