Impaired Humoral Response to Vaccines Among HIV-exposed Uninfected Infants

Overview

Journal Clin Vaccine Immunol

Publisher American Society for Microbiology

Specialties Allergy & Immunology
Pathology

Date 2011 Jul 22

PMID 21775515

Citations 39

Authors

Beatriz Mariana Abramczuk

Tais Nitsch Mazzola

Yara Maria Franco Moreno

Tatiane Queiroz Zorzeto

Wagner Quintilio

Paulo Silva Wolf

Maria Heloisa Blotta

Andre Moreno Morcillo

Marcos Tadeu Nolasco da Silva

Maria Marluce Dos Santos Vilela

Affiliations

Soon will be listed here.

Abstract

Little is known about the vaccine protective response for infants born from HIV-infected mothers. We evaluated the antibody response to hepatitis B, tetanus, and diphtheria vaccine in vertically HIV-exposed uninfected infants and compared them to those of control infants not exposed to the virus. The quantitative determination of specific neutralizing antibodies against hepatitis B, diphtheria, and tetanus were performed blindly on serum samples. The results showed that 6.7% of the HIV-exposed uninfected individuals were nonresponders to hepatitis B vaccine (anti-HBs titer, <10 mIU/ml), and 64.4% were very good responders (anti-HBs titer, ≥1,000 mIU/ml), whereas only 3.6% of the nonexposed infants were nonresponders (χ(2)=10.93; 1 df). The HIV-exposed uninfected infants showed protective titers for diphtheria and tetanus but lower geometric mean anti-tetanus titers compared to those of the HIV-unexposed infants. Our data point to the necessity of evaluating vaccine immune responses in these children and reinforced that alterations in lymphocyte numbers and functions reported for newborns from HIV-infected mothers interfere with the vaccine response.

Citing Articles

Infectivity and Immunogenicity of Live-Attenuated Respiratory Syncytial Virus Vaccines in Human Immunodeficiency Virus-Exposed Uninfected Children.

Kelly M, Cunningham C, McFarland E, Giganti M, Lindsey J, Perlowski C Open Forum Infect Dis. 2024; 11(12):ofae679.

PMID: 39610407 PMC: 11604081. DOI: 10.1093/ofid/ofae679.

HIV-exposed uninfected infants' immune defects: From pathogen sensing, oxidative burst to antigens responses.

Djoba Siawaya J, Maloupazoa Siawaya A iScience. 2023; 26(12):108427.

PMID: 38077134 PMC: 10708997. DOI: 10.1016/j.isci.2023.108427.

Human immunodeficiency virus and antiretroviral therapy-mediated immune cell metabolic dysregulation in children born to HIV-infected women: potential clinical implications.

Mataramvura H, Bunders M, Duri K Front Immunol. 2023; 14:1182217.

PMID: 37350953 PMC: 10282157. DOI: 10.3389/fimmu.2023.1182217.

Kinetics of pneumococcal antibodies among HIV-exposed, uninfected infants in Botswana.

Uffman E, Li S, Chen J, Allen N, Boiditswe S, Fouda G Vaccine. 2022; 40(33):4764-4771.

PMID: 35773120 PMC: 9912097. DOI: 10.1016/j.vaccine.2022.06.059.

Defective Monocyte Enzymatic Function and an Inhibitory Immune Phenotype in Human Immunodeficiency Virus-Exposed Uninfected African Infants in the Era of Antiretroviral Therapy.

Afran L, Jambo K, Nedi W, Miles D, Kiran A, Banda D J Infect Dis. 2022; 226(7):1243-1255.

PMID: 35403683 PMC: 9518837. DOI: 10.1093/infdis/jiac133.

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