The Effect of Changes in Adrenal Blood Flow on Adrenal Cortical Responses to Adrenocorticotrophin in Conscious Calves

Overview

Journal J Physiol

Specialty Physiology

Date 1990 Oct 1

PMID 2177504

Citations 4

Authors

C T Jones

A V Edwards

S R Bloom

Affiliations

Soon will be listed here.

Abstract

1. The effect of varying adrenal blood flow on the rate at which it was estimated that adrenocorticotrophin (ACTH) was presented to the adrenal gland was related to right adrenal cortisol output in conscious calves fitted with 'adrenal clamps'. 2. Intra-aortic infusions of endothelin at either 15.0 or 7.5 pmol min-1 kg-1 produced a substantial fall in right adrenal blood flow which was dose-related over this range. There was an associated fall in right adrenal cortisol output and cortisol output was linearly related to estimated ACTH presentation to the gland over the whole range investigated. The changes in adrenal cortisol output were reflected by changes in the concentration of cortisol in the peripheral plasma, which could be attributed entirely to the fluctuations in adrenal cortisol output. 3. It is concluded that delivery of ACTH to the adrenal gland is flow dependent over the physiological range in these animals and that changes in adrenal cortical blood flow can therefore be expected to result in changes in adrenal output due to variations in the presentation rate of ACTH.

Citing Articles

Adrenal Gland Microenvironment and Its Involvement in the Regulation of Stress-Induced Hormone Secretion during Sepsis.

Kanczkowski W, Sue M, Bornstein S Front Endocrinol (Lausanne). 2016; 7:156.

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Autonomic control of adrenal function.

Edwards A, Jones C J Anat. 1993; 183 ( Pt 2):291-307.

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Synergism in the autonomic regulation of parotid secretion of protein in sheep.

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The role of corticotrophin releasing factor in relation to the neural control of adrenal function in conscious calves.

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