Luteinizing Hormone and Its Dilemma in Ovulation Induction

Overview

Journal J Hum Reprod Sci

Date 2011 Jul 21

PMID 21772731

Citations 29

Authors

Pratap Kumar

Sameer Farouk Sait

Affiliations

Soon will be listed here.

Abstract

Concept of a 'therapeutic window' of luteinizing hormone (LH) for successful conception in assisted reproductive technology and ovulation induction has been reviewed in this literature. The separate but complementary roles of follicle stimulating hormone and LH in stimulating folliculogenesis and ovulation are well established. Levels under which low LH concentrations may be equally or suboptimally needed for oocyte quality and subsequent embryonic development competence has been reviewed along with the data related to the high levels of LH promoting follicular atresia.

Citing Articles

Available Oocytes rate as a predictor of clinical pregnancy outcomes in controlled ovarian stimulation: A retrospective analysis of 7933 Cycles.

Lin P, Li R, Zhu S, Zheng X, Xu H, Zheng B Pak J Med Sci. 2024; 40(11):2485-2494.

PMID: 39634878 PMC: 11613380. DOI: 10.12669/pjms.40.11.10094.

Sexual dimorphism in a mouse model of Friedreich's ataxia with severe cardiomyopathy.

Salinas L, Montgomery C, Figueroa F, Thai P, Chiamvimonvat N, Cortopassi G Commun Biol. 2024; 7(1):1250.

PMID: 39363102 PMC: 11449905. DOI: 10.1038/s42003-024-06962-4.

Effect of LH level on HCG trigger day on clinical outcomes in patients with diminished ovarian reserve undergoing GnRH-antagonist protocol.

Zhang Q, Zhang K, Gao Y, He S, Meng Y, Ming L Reprod Biol Endocrinol. 2024; 22(1):107.

PMID: 39175038 PMC: 11340131. DOI: 10.1186/s12958-024-01280-0.

Benefit from luteal phase progestin primed ovarian stimulation with clomiphene citrate supplementation in young women with diminished ovarian reserve: a retrospective study.

Chen Q, Huang X, Yang H, Lin Y Zhejiang Da Xue Xue Bao Yi Xue Ban. 2024; 53(3):297-305.

PMID: 38763766 PMC: 11348691. DOI: 10.3724/zdxbyxb-2023-0533.

Current Insights in Prolactin Signaling and Ovulatory Function.

Szukiewicz D Int J Mol Sci. 2024; 25(4).

PMID: 38396659 PMC: 10889014. DOI: 10.3390/ijms25041976.

References

Tarlatzis B, Tavmergen E, Szamatowicz M, Barash A, Amit A, Levitas E . The use of recombinant human LH (lutropin alfa) in the late stimulation phase of assisted reproduction cycles: a double-blind, randomized, prospective study. Hum Reprod. 2005; 21(1):90-4. DOI: 10.1093/humrep/dei293. View

Stanger J, Yovich J . Reduced in-vitro fertilization of human oocytes from patients with raised basal luteinizing hormone levels during the follicular phase. Br J Obstet Gynaecol. 1985; 92(4):385-93. DOI: 10.1111/j.1471-0528.1985.tb01113.x. View

Jakubowicz D, Iuorno M, Jakubowicz S, Roberts K, Nestler J . Effects of metformin on early pregnancy loss in the polycystic ovary syndrome. J Clin Endocrinol Metab. 2002; 87(2):524-9. DOI: 10.1210/jcem.87.2.8207. View

Balasch J, Vidal E, Penarrubia J, Casamitjana R, Carmona F, Creus M . Suppression of LH during ovarian stimulation: analysing threshold values and effects on ovarian response and the outcome of assisted reproduction in down-regulated women stimulated with recombinant FSH. Hum Reprod. 2001; 16(8):1636-43. DOI: 10.1093/humrep/16.8.1636. View

McCartney C, Eagleson C, Marshall J . Regulation of gonadotropin secretion: implications for polycystic ovary syndrome. Semin Reprod Med. 2003; 20(4):317-26. DOI: 10.1055/s-2002-36706. View

Homburg R, Armar N, Eshel A, Adams J, Jacobs H . Influence of serum luteinising hormone concentrations on ovulation, conception, and early pregnancy loss in polycystic ovary syndrome. BMJ. 1988; 297(6655):1024-6. PMC: 1834779. DOI: 10.1136/bmj.297.6655.1024. View

Filicori M, Cognigni G, Samara A, Melappioni S, Perri T, Cantelli B . The use of LH activity to drive folliculogenesis: exploring uncharted territories in ovulation induction. Hum Reprod Update. 2002; 8(6):543-57. DOI: 10.1093/humupd/8.6.543. View

Balasch J, Creus M, Fabregues F, Civico S, Carmona F, Puerto B . The effect of exogenous luteinizing hormone (LH) on oocyte viability: evidence from a comparative study using recombinant human follicle-stimulating hormone (FSH) alone or in combination with recombinant LH for ovarian stimulation in.... J Assist Reprod Genet. 2001; 18(5):250-6. PMC: 3455335. DOI: 10.1023/a:1016662100572. View

Chappel S, Howles C . Reevaluation of the roles of luteinizing hormone and follicle-stimulating hormone in the ovulatory process. Hum Reprod. 1991; 6(9):1206-12. DOI: 10.1093/oxfordjournals.humrep.a137513. View

10.

Ferrari B, Barusi L, Coppola F . Clinical and endocrine effects of ovulation induction with FSH and hCG supplementation in low responders in the midfollicular phase. A pilot study. J Reprod Med. 2002; 47(2):137-43. View

11.

Hillier S, Whitelaw P, Smyth C . Follicular oestrogen synthesis: the 'two-cell, two-gonadotrophin' model revisited. Mol Cell Endocrinol. 1994; 100(1-2):51-4. DOI: 10.1016/0303-7207(94)90278-x. View

12.

Westergaard L, Erb K, Laursen S, Rex S, Rasmussen P . Human menopausal gonadotropin versus recombinant follicle-stimulating hormone in normogonadotropic women down-regulated with a gonadotropin-releasing hormone agonist who were undergoing in vitro fertilization and intracytoplasmic sperm injection: a.... Fertil Steril. 2001; 76(3):543-9. DOI: 10.1016/s0015-0282(01)01973-2. View

13.

Regan L, Owen E, Jacobs H . Hypersecretion of luteinising hormone, infertility, and miscarriage. Lancet. 1990; 336(8724):1141-4. DOI: 10.1016/0140-6736(90)92765-a. View

14.

Filicori M, Cognigni G, Taraborrelli S, Spettoli D, Ciampaglia W, Tabarelli de Fatis C . Luteinzing hormone activity in menotropins optimizes folliculogenesis and treatment in controlled ovarian stimulation. J Clin Endocrinol Metab. 2001; 86(1):337-43. DOI: 10.1210/jcem.86.1.7108. View

15.

Yoshimura Y, Wallach E . Studies of the mechanism(s) of mammalian ovulation. Fertil Steril. 1987; 47(1):22-34. View

16.

Howles C . Role of LH and FSH in ovarian function. Mol Cell Endocrinol. 2000; 161(1-2):25-30. DOI: 10.1016/s0303-7207(99)00219-1. View

17.

Howles C, Macnamee M, Edwards R, Goswamy R, STEPTOE P . Effect of high tonic levels of luteinising hormone on outcome of in-vitro fertilisation. Lancet. 1986; 2(8505):521-2. DOI: 10.1016/s0140-6736(86)90395-8. View

18.

Zeleznik A, Hillier S . The role of gonadotropins in the selection of the preovulatory follicle. Clin Obstet Gynecol. 1984; 27(4):927-40. DOI: 10.1097/00003081-198412000-00014. View

19.

Shoham Z, Jacobs H, INSLER V . Luteinizing hormone: its role, mechanism of action, and detrimental effects when hypersecreted during the follicular phase. Fertil Steril. 1993; 59(6):1153-61. DOI: 10.1016/s0015-0282(16)55968-8. View

20.

Humaidan P, Bungum L, Bungum M, Andersen C . Ovarian response and pregnancy outcome related to mid-follicular LH levels in women undergoing assisted reproduction with GnRH agonist down-regulation and recombinant FSH stimulation. Hum Reprod. 2002; 17(8):2016-21. DOI: 10.1093/humrep/17.8.2016. View