Potential Role of Nuclear Factor κB in Diabetic Cardiomyopathy

Overview

Journal Mediators Inflamm

Publisher Wiley

Specialties Biochemistry
Pathology

Date 2011 Jul 21

PMID 21772665

Citations 78

Authors

O Lorenzo

B Picatoste

S Ares-Carrasco

E Ramirez

J Egido

J Tunon

Affiliations

Soon will be listed here.

Abstract

Diabetic cardiomyopathy entails the cardiac injury induced by diabetes independently of any vascular disease or hypertension. Some transcription factors have been proposed to control the gene program involved in the setting and development of related processes. Nuclear factor-kappa B is a pleiotropic transcription factor associated to the regulation of many heart diseases. However, the nuclear factor-kappa B role in diabetic cardiomyopathy is under investigation. In this paper, we review the nuclear factor-kappa B pathway and its role in several processes that have been linked to diabetic cardiomyopathy, such as oxidative stress, inflammation, endothelial dysfunction, fibrosis, hypertrophy and apoptosis.

Citing Articles

Advances of research in diabetic cardiomyopathy: diagnosis and the emerging application of sequencing.

He Q, Lai Z, Zhai Z, Zou B, Shi Y, Feng C Front Cardiovasc Med. 2025; 11:1501735.

PMID: 39872882 PMC: 11769946. DOI: 10.3389/fcvm.2024.1501735.

Critical Appraisal of Pharmaceutical Therapy in Diabetic Cardiomyopathy-Challenges and Prospectives.

Khattab E, Kyriakou M, Leonidou E, Sokratous S, Mouzarou A, Myrianthefs M Pharmaceuticals (Basel). 2025; 18(1).

PMID: 39861195 PMC: 11768626. DOI: 10.3390/ph18010134.

The Associations between Asprosine, Clusterin, Zinc Alpha-2-Glycoprotein, Nuclear Factor Kappa B, and Peroxisome Proliferator-Activated Receptor Gamma in the Development of Complications in Type 2 Diabetes Mellitus.

Senyigit A, Durmus S, Tabak O, Oruc A, Uzun H, Ekinci I J Clin Med. 2024; 13(20).

PMID: 39458076 PMC: 11508428. DOI: 10.3390/jcm13206126.

Diabetic Cardiomyopathy: Role of Cell Death, Exosomes, Fibrosis and Epicardial Adipose Tissue.

Galeone A, Annicchiarico A, Buccoliero C, Barile B, Luciani G, Onorati F Int J Mol Sci. 2024; 25(17).

PMID: 39273428 PMC: 11395197. DOI: 10.3390/ijms25179481.

Insulin-Heart Axis: Bridging Physiology to Insulin Resistance.

Caturano A, Galiero R, Vetrano E, Sardu C, Rinaldi L, Russo V Int J Mol Sci. 2024; 25(15).

PMID: 39125938 PMC: 11313400. DOI: 10.3390/ijms25158369.

References

Hikoso S, Yamaguchi O, Nakano Y, Takeda T, Omiya S, Mizote I . The I{kappa}B kinase {beta}/nuclear factor {kappa}B signaling pathway protects the heart from hemodynamic stress mediated by the regulation of manganese superoxide dismutase expression. Circ Res. 2009; 105(1):70-9. DOI: 10.1161/CIRCRESAHA.108.193318. View

Westermann D, Van Linthout S, Dhayat S, Dhayat N, Escher F, Bucker-Gartner C . Cardioprotective and anti-inflammatory effects of interleukin converting enzyme inhibition in experimental diabetic cardiomyopathy. Diabetes. 2007; 56(7):1834-41. DOI: 10.2337/db06-1662. View

Purcell N, Tang G, Yu C, Mercurio F, DiDonato J, Lin A . Activation of NF-kappa B is required for hypertrophic growth of primary rat neonatal ventricular cardiomyocytes. Proc Natl Acad Sci U S A. 2001; 98(12):6668-73. PMC: 34410. DOI: 10.1073/pnas.111155798. View

Valen G, Yan Z, Hansson G . Nuclear factor kappa-B and the heart. J Am Coll Cardiol. 2001; 38(2):307-14. DOI: 10.1016/s0735-1097(01)01377-8. View

van Heerebeek L, Hamdani N, Handoko M, Falcao-Pires I, Musters R, Kupreishvili K . Diastolic stiffness of the failing diabetic heart: importance of fibrosis, advanced glycation end products, and myocyte resting tension. Circulation. 2007; 117(1):43-51. DOI: 10.1161/CIRCULATIONAHA.107.728550. View

Westermarck J, Kahari V . Regulation of matrix metalloproteinase expression in tumor invasion. FASEB J. 1999; 13(8):781-92. View

Westermann D, Rutschow S, Jager S, Linderer A, Anker S, Riad A . Contributions of inflammation and cardiac matrix metalloproteinase activity to cardiac failure in diabetic cardiomyopathy: the role of angiotensin type 1 receptor antagonism. Diabetes. 2007; 56(3):641-6. DOI: 10.2337/db06-1163. View

Brown K, Claudio E, Siebenlist U . The roles of the classical and alternative nuclear factor-kappaB pathways: potential implications for autoimmunity and rheumatoid arthritis. Arthritis Res Ther. 2008; 10(4):212. PMC: 2575629. DOI: 10.1186/ar2457. View

Al-Maghrebi M, Benter I, Diz D . Endogenous angiotensin-(1-7) reduces cardiac ischemia-induced dysfunction in diabetic hypertensive rats. Pharmacol Res. 2009; 59(4):263-8. PMC: 2682227. DOI: 10.1016/j.phrs.2008.12.008. View

10.

Schorlemmer A, Matter M, Shohet R . Cardioprotective signaling by endothelin. Trends Cardiovasc Med. 2009; 18(7):233-9. PMC: 4048746. DOI: 10.1016/j.tcm.2008.11.005. View

11.

Min W, Bin Z, Quan Z, Hui Z, Sheng F . The signal transduction pathway of PKC/NF-kappa B/c-fos may be involved in the influence of high glucose on the cardiomyocytes of neonatal rats. Cardiovasc Diabetol. 2009; 8:8. PMC: 2652442. DOI: 10.1186/1475-2840-8-8. View

12.

Chen F . Endogenous inhibitors of nuclear factor-kappaB, an opportunity for cancer control. Cancer Res. 2004; 64(22):8135-8. DOI: 10.1158/0008-5472.CAN-04-2096. View

13.

Frangogiannis N . The immune system and cardiac repair. Pharmacol Res. 2008; 58(2):88-111. PMC: 2642482. DOI: 10.1016/j.phrs.2008.06.007. View

14.

Craig R, Wagner M, McCardle T, Craig A, Glembotski C . The cytoprotective effects of the glycoprotein 130 receptor-coupled cytokine, cardiotrophin-1, require activation of NF-kappa B. J Biol Chem. 2001; 276(40):37621-9. DOI: 10.1074/jbc.M103276200. View

15.

Newby A . Metalloproteinase expression in monocytes and macrophages and its relationship to atherosclerotic plaque instability. Arterioscler Thromb Vasc Biol. 2008; 28(12):2108-14. DOI: 10.1161/ATVBAHA.108.173898. View

16.

Rice T, Lumsden A . Optimal medical management of peripheral arterial disease. Vasc Endovascular Surg. 2006; 40(4):312-27. DOI: 10.1177/1538574406291835. View

17.

Fiordaliso F, de Angelis N, Bai A, Cuccovillo I, Salio M, Serra D . Effect of beta-adrenergic and renin-angiotensin system blockade on myocyte apoptosis and oxidative stress in diabetic hypertensive rats. Life Sci. 2007; 81(12):951-9. DOI: 10.1016/j.lfs.2007.05.027. View

18.

Barnes P, Adcock I . Glucocorticoid resistance in inflammatory diseases. Lancet. 2009; 373(9678):1905-17. DOI: 10.1016/S0140-6736(09)60326-3. View

19.

Liston P, Roy N, Tamai K, Lefebvre C, Baird S, Farahani R . Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. Nature. 1996; 379(6563):349-53. DOI: 10.1038/379349a0. View

20.

Palomer X, Alvarez-Guardia D, Rodriguez-Calvo R, Coll T, Laguna J, Davidson M . TNF-alpha reduces PGC-1alpha expression through NF-kappaB and p38 MAPK leading to increased glucose oxidation in a human cardiac cell model. Cardiovasc Res. 2008; 81(4):703-12. DOI: 10.1093/cvr/cvn327. View