Pathogenesis of Dermatophytoses

Overview

Journal Indian J Dermatol

Specialty Dermatology

Date 2011 Jul 21

PMID 21772583

Citations 20

Authors

Ram Tainwala

Yk Sharma

Affiliations

Soon will be listed here.

Abstract

Dermatophytes can survive solely on outer cornified layers of the skin. The ability of certain fungi to adhere to particular host arises from numerous mechanisms and host factors, including the ability to adapt to the human body. Natural infection is acquired by the deposition of viable arthrospores or hyphae on the surface of the susceptible individual. After the inoculation in the host skin, suitable conditions favor the infection to progress through the stages of adherence and penetration. Development of host response is mostly by a T-cell mediated response of delayed-type hypersensitivity. Antibody formation does not seem to be protective. Natural defenses against dermatophytes depend on both immunological and nonimmunological mechanisms.

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