Influence of Alpha-MSH and ACTH on Cortical Bone Remodelling in Hypophysectomized Rats
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Abstract
Hypophysectomy increases both periosteal resorption and endosteal apposition along the femur diaphysis in rat. Administration of alpha-MSH decreased the periosteal resorption but had no effect on the endosteal apposition. ACTH had only minor effects on the endosteum. Thus, alpha-MSH and ACTH, in the doses used, have different effects on cortical bone in rat. The effect of alpha-MSH on cortical bone could be an effect of the hormone alone or by its stimulation of other factors.
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Bohm M, Grassel S Endocr Rev. 2012; 33(4):623-51.
PMID: 22736674 PMC: 3410228. DOI: 10.1210/er.2011-1016.
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