PDGF: the Nuts and Bolts of Signalling Toolbox

Overview

Journal Tumour Biol

Publisher Sage Publications

Specialty Oncology

Date 2011 Jul 20

PMID 21769672

Citations 15

Authors

Ammad Ahmad Farooqi

Salman Waseem

Asma M Riaz

Bilal Ahmed Dilawar

Shahzeray Mukhtar

Sehrish Minhaj

Makhdoom Saad Waseem

Suneel Daniel

Beenish Ali Malik

Ali Nawaz

Shahzad Bhatti

Affiliations

Soon will be listed here.

Abstract

PDGF is a growth factor and is extensively involved in multi-dimensional cellular dynamics. It switches on a plethora of molecules other than its classical pathway. It is engaged in various transitions of development; however, if the unleashed potentials lead astray, it brings forth tumourigenesis. Conventionally, it has been assumed that the components of this signalling pathway show fidelity and act with a high degree of autonomy. However, as illustrated by the PDGF signal transduction, reinterpretation of recent data suggests that machinery is often shared between multiple pathways, and other components crosstalk to each other through multiple mechanisms. It is important to note that metastatic cascade is an intricate process that we have only begun to understand in recent years. Many of the early steps of this PDGF cascade are not readily targetable in the clinic. In this review, we will unravel the paradoxes with reference to mitrons and cellular plasticity and discuss how disruption of signalling cascade triggers cellular proliferation phase transition and metastasis. We will also focus on the therapeutic interventions to counteract resultant molecular disorders.

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