The Cellular Basis for Animal Regeneration

Overview

Journal Dev Cell

Publisher Cell Press

Specialties Cell Biology
Reproductive Medicine

Date 2011 Jul 19

PMID 21763617

Citations 227

Authors

Elly M Tanaka

Peter W Reddien

Affiliations

Soon will be listed here.

Abstract

The ability of animals to regenerate missing parts is a dramatic and poorly understood aspect of biology. The sources of new cells for these regenerative phenomena have been sought for decades. Recent advances involving cell fate tracking in complex tissues have shed new light on the cellular underpinnings of regeneration in Hydra, planarians, zebrafish, Xenopus, and Axolotl. Planarians accomplish regeneration with use of adult pluripotent stem cells, whereas several vertebrates utilize a collection of lineage-restricted progenitors from different tissues. Together, an array of cellular strategies-from pluripotent stem cells to tissue-specific stem cells and dedifferentiation-are utilized for regeneration.

Citing Articles

Extracellular Vesicles Derived From Regenerating Tissue Promote Stem Cell Proliferation in the Planarian .

Avalos Najera P, Wong L, Forsthoefel D J Extracell Biol. 2025; 4(3):e70040.

PMID: 40066202 PMC: 11891293. DOI: 10.1002/jex2.70040.

Combined fluorescent hybridization and F--EdU staining on whole mount .

Ishan M, Skipper I, Rozario T Biol Methods Protoc. 2025; 10(1):bpaf011.

PMID: 40060950 PMC: 11886792. DOI: 10.1093/biomethods/bpaf011.

Stem cells (neoblasts) and positional information jointly dominate regeneration in planarians.

Chen X Heliyon. 2025; 11(2):e41833.

PMID: 39877626 PMC: 11773080. DOI: 10.1016/j.heliyon.2025.e41833.

Regeneration, Regengrow and Tissue Repair in Animals: Evolution Indicates That No Regeneration Occurs in Terrestrial Environments but Only Recovery Healing.

Alibardi L J Dev Biol. 2025; 13(1.

PMID: 39846631 PMC: 11755470. DOI: 10.3390/jdb13010002.

Tokay gecko tail regeneration involves temporally collinear expression of HOXC genes and early expression of satellite cell markers.

Nurhidayat L, Benes V, Blom S, Gomes I, Firdausi N, de Bakker M BMC Biol. 2025; 23(1):6.

PMID: 39780185 PMC: 11715542. DOI: 10.1186/s12915-024-02111-9.

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