In Vitro Effects of Novel Toothpaste Actives on Components of Oral Malodour

Overview

Journal Int Dent J

Publisher Elsevier

Specialty Dentistry

Date 2011 Jul 19

PMID 21762158

Citations 6

Authors

Gary R Burnett

Abish S Stephen

Robert L Pizzey

David J Bradshaw

Affiliations

Soon will be listed here.

Abstract

Objectives: To evaluate the efficacy of a novel toothpaste containing zinc ions and o-cymen-5-ol to reduce volatile sulfur compounds (VSCs) in in vitro models and to elucidate the mode of action for any activity observed.

Methods: Three models were employed, a chemical neutralisation model to evaluate the chemical reactivity of toothpaste slurries to VSCs, a biofilm perfusion model to measure activity in an orally-relevant biofilm and a planktonic bacterial model to measure antimicrobial effects.

Results: The models showed that zinc ions were able to react chemically with hydrogen sulfide to remove this odorous component of halitotic breath. This activity was confirmed within a complex biofilm model, with over 90% of hydrogen sulfide removed from perfusate gas by a slurry of the test toothpaste.

Conclusions: This work provides a mode of action for the clinically observed reduction in VSCs seen for up to 12 hours post brushing with this novel toothpaste.

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