Lactobacillus Rhamnosus GG As an Effective Probiotic for Murine Giardiasis

Overview

Journal Interdiscip Perspect Infect Dis

Publisher Wiley

Date 2011 Jul 16

PMID 21760784

Citations 20

Authors

Nisha Goyal

Ram Prakash Tiwari

Geeta Shukla

Affiliations

Soon will be listed here.

Abstract

The gut microflora is an important constituent in the intestinal mucosal barrier and has been introduced as the concept of probiotic therapy that beneficially affects the host by improving its intestinal microbial balance. Therefore, the main objective of the study was to explore the protective potential of various lactobacilli strains for murine giardiasis. By experimentation, it was found that the probiotic supplementation of either Lactobacillus casei, L. acidophilus, L. plantarum, or L. rhamnosus GG, 7 days prior to inoculation with G. lamblia trophozoites, reduced the rate of cyst excretion compared with Giardia-infected mice. Interestingly, L. GG was found to be the most effective probiotic in reducing the duration of giardia cycle and acts as an effective prophylactic probiotic for murine giardiasis but needs to be clinically correlated due to entirely different human microflora.

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References

Heyman M, Menard S . Probiotic microorganisms: how they affect intestinal pathophysiology. Cell Mol Life Sci. 2002; 59(7):1151-65. PMC: 11337510. DOI: 10.1007/s00018-002-8494-7. View

Humen M, DE Antoni G, Benyacoub J, Costas M, Cardozo M, Kozubsky L . Lactobacillus johnsonii La1 antagonizes Giardia intestinalis in vivo. Infect Immun. 2005; 73(2):1265-9. PMC: 547090. DOI: 10.1128/IAI.73.2.1265-1269.2005. View

Cebra J . Influences of microbiota on intestinal immune system development. Am J Clin Nutr. 1999; 69(5):1046S-1051S. DOI: 10.1093/ajcn/69.5.1046s. View

Benyacoub J, Perez P, Rochat F, Saudan K, Reuteler G, Antille N . Enterococcus faecium SF68 enhances the immune response to Giardia intestinalis in mice. J Nutr. 2005; 135(5):1171-6. DOI: 10.1093/jn/135.5.1171. View

Upcroft P, Upcroft J . Drug targets and mechanisms of resistance in the anaerobic protozoa. Clin Microbiol Rev. 2001; 14(1):150-64. PMC: 88967. DOI: 10.1128/CMR.14.1.150-164.2001. View

Berkman D, Lescano A, Gilman R, Lopez S, Black M . Effects of stunting, diarrhoeal disease, and parasitic infection during infancy on cognition in late childhood: a follow-up study. Lancet. 2002; 359(9306):564-71. DOI: 10.1016/S0140-6736(02)07744-9. View

Shukla G, Devi P, Sehgal R . Effect of Lactobacillus casei as a probiotic on modulation of giardiasis. Dig Dis Sci. 2008; 53(10):2671-9. DOI: 10.1007/s10620-007-0197-3. View

Roxstrom-Lindquist K, Palm D, Reiner D, Ringqvist E, Svard S . Giardia immunity--an update. Trends Parasitol. 2005; 22(1):26-31. DOI: 10.1016/j.pt.2005.11.005. View

Ratanapo S, Mungthin M, Soontrapa S, Faithed C, Siripattanapipong S, Rangsin R . Multiple modes of transmission of giardiasis in primary schoolchildren of a rural community, Thailand. Am J Trop Med Hyg. 2008; 78(4):611-5. View

10.

Gauffin C, Aguero G, Perdigon G . Adjuvant effects of Lactobacillus casei added to a renutrition diet in a malnourished mouse model. Biocell. 2002; 26(1):35-48. View

11.

Lievin V, Brassart D, Neeser J, Servin A, Hudault S . The human Lactobacillus acidophilus strain LA1 secretes a nonbacteriocin antibacterial substance(s) active in vitro and in vivo. Appl Environ Microbiol. 1997; 63(7):2747-53. PMC: 168570. DOI: 10.1128/aem.63.7.2747-2753.1997. View

12.

Lemee V, Zaharia I, Nevez G, Rabodonirina M, Brasseur P, Ballet J . Metronidazole and albendazole susceptibility of 11 clinical isolates of Giardia duodenalis from France. J Antimicrob Chemother. 2000; 46(5):819-21. DOI: 10.1093/jac/46.5.819. View

13.

Gardner T, Hill D . Treatment of giardiasis. Clin Microbiol Rev. 2001; 14(1):114-28. PMC: 88965. DOI: 10.1128/CMR.14.1.114-128.2001. View

14.

Isolauri E, Sutas Y, Kankaanpaa P, Arvilommi H, Salminen S . Probiotics: effects on immunity. Am J Clin Nutr. 2001; 73(2 Suppl):444S-450S. DOI: 10.1093/ajcn/73.2.444s. View

15.

Castagliuolo I, Riegler M, Valenick L, Lamont J, Pothoulakis C . Saccharomyces boulardii protease inhibits the effects of Clostridium difficile toxins A and B in human colonic mucosa. Infect Immun. 1998; 67(1):302-7. PMC: 96311. DOI: 10.1128/IAI.67.1.302-307.1999. View

16.

Yuki N, Shimazaki T, Kushiro A, Watanabe K, Uchida K, Yuyama T . Colonization of the stratified squamous epithelium of the nonsecreting area of horse stomach by lactobacilli. Appl Environ Microbiol. 2000; 66(11):5030-4. PMC: 92416. DOI: 10.1128/AEM.66.11.5030-5034.2000. View