In Vitro Prostaglandin E2 Production by Glioblastoma Cells and Its Effect on Interleukin-2 Activation of Oncolytic Lymphocytes

Overview

Journal J Neurooncol

Publisher Springer

Date 1990 Oct 1

PMID 2175768

Citations 22

Authors

Y Sawamura

A C Diserens

N de Tribolet

Affiliations

Soon will be listed here.

Abstract

Glioblastoma cells constitutively produce various amounts of PGE2 (prostaglandin E2) in vitro. The amounts of PGE2 found in the conditioned medium of the glioblastoma cultures (less than 5 ng/ml) were not enough to inhibit the IL-2 (interleukin-2) activation of peripheral blood lymphocytes. However the amount of PGE2 produced by approximately 1 x 10(7) of the glioblastoma cells can be assumed to suppress the generation of IL-2-induced killing activity against glioblastoma cells.

Citing Articles

Dendritic cell therapy for neurospoagioma: Immunomodulation mediated by tumor vaccine.

Qian D, Liu Y, Zheng J, Cai J Cell Death Discov. 2024; 10(1):11.

PMID: 38184649 PMC: 10771477. DOI: 10.1038/s41420-023-01782-7.

The Promoting Effect of Traumatic Brain Injury on the Incidence and Progression of Glioma: A Review of Clinical and Experimental Research.

Lan Y, Zhu Y, Chen G, Zhang J J Inflamm Res. 2021; 14:3707-3720.

PMID: 34377008 PMC: 8350857. DOI: 10.2147/JIR.S325678.

Immunogenicity of high-dose influenza vaccination in patients with primary central nervous system malignancy.

Strowd R, Russell G, Hsu F, Carter A, Chan M, Tatter S Neurooncol Pract. 2019; 5(3):176-183.

PMID: 31385974 PMC: 6655350. DOI: 10.1093/nop/npx035.

Irradiation to Improve the Response to Immunotherapeutic Agents in Glioblastomas.

Nesseler J, Schaue D, McBride W, Lee M, Kaprealian T, Niclou S Adv Radiat Oncol. 2019; 4(2):268-282.

PMID: 31011672 PMC: 6460102. DOI: 10.1016/j.adro.2018.11.005.

Ex vivo-expanded highly purified natural killer cells in combination with temozolomide induce antitumor effects in human glioblastoma cells in vitro.

Tanaka Y, Nakazawa T, Nakamura M, Nishimura F, Matsuda R, Omoto K PLoS One. 2019; 14(3):e0212455.

PMID: 30840664 PMC: 6402639. DOI: 10.1371/journal.pone.0212455.

References

Chouaib S, Bertoglio J . Prostaglandins E as modulators of the immune response. Lymphokine Res. 1988; 7(3):237-45. View

Saris S, Rosenberg S, Friedman R, Rubin J, Barba D, Oldfield E . Penetration of recombinant interleukin-2 across the blood-cerebrospinal fluid barrier. J Neurosurg. 1988; 69(1):29-34. DOI: 10.3171/jns.1988.69.1.0029. View

Siepl C, Bodmer S, Frei K, MacDonald H, de Martin R, Hofer E . The glioblastoma-derived T cell suppressor factor/transforming growth factor-beta 2 inhibits T cell growth without affecting the interaction of interleukin 2 with its receptor. Eur J Immunol. 1988; 18(4):593-600. DOI: 10.1002/eji.1830180416. View

Barba D, Saris S, Holder C, Rosenberg S, Oldfield E . Intratumoral LAK cell and interleukin-2 therapy of human gliomas. J Neurosurg. 1989; 70(2):175-82. DOI: 10.3171/jns.1989.70.2.0175. View

CASTELLI M, Chiabrando C, Fanelli R, Martelli L, Butti G, Gaetani P . Prostaglandin and thromboxane synthesis by human intracranial tumors. Cancer Res. 1989; 49(6):1505-8. View

Goodwin J, Ceuppens J . Regulation of the immune response by prostaglandins. J Clin Immunol. 1983; 3(4):295-315. DOI: 10.1007/BF00915791. View

Kennedy M, Stobo J, Goldyne M . In vitro synthesis of prostaglandins and related lipids by populations of human peripheral blood mononuclear cells. Prostaglandins. 1980; 20(1):135-45. DOI: 10.1016/0090-6980(80)90013-1. View

Hancock W, Pleau M, Kobzik L . Recombinant granulocyte-macrophage colony-stimulating factor down-regulates expression of IL-2 receptor on human mononuclear phagocytes by induction of prostaglandin E. J Immunol. 1988; 140(9):3021-5. View

Miescher S, Whiteside T, Tribolet N, Von Fliedner V . In situ characterization, clonogenic potential, and antitumor cytolytic activity of T lymphocytes infiltrating human brain cancers. J Neurosurg. 1988; 68(3):438-48. DOI: 10.3171/jns.1988.68.3.0438. View

10.

Garcia-Penarrubia P, Bankhurst A, Koster F . Prostaglandins from human T suppressor/cytotoxic cells modulate natural killer antibacterial activity. J Exp Med. 1989; 170(2):601-6. PMC: 2189404. DOI: 10.1084/jem.170.2.601. View

11.

Plaut M . Lymphocyte hormone receptors. Annu Rev Immunol. 1987; 5:621-69. DOI: 10.1146/annurev.iy.05.040187.003201. View

12.

Naganuma H, Kimurat R, Sasaki A, Fukamachi A, Nukui H, Tasaka K . Complete remission of recurrent glioblastoma multiforme following local infusions of lymphokine activated killer cells. Case report. Acta Neurochir (Wien). 1989; 99(3-4):157-60. DOI: 10.1007/BF01402326. View

13.

Sawamura Y, Hosokawa M, Kuppner M, Kobayashi H, Aida T, Abe H . Antitumor activity and surface phenotypes of human glioma-infiltrating lymphocytes after in vitro expansion in the presence of interleukin 2. Cancer Res. 1989; 49(7):1843-9. View

14.

Simkin N, Jelinek D, Lipsky P . Inhibition of human B cell responsiveness by prostaglandin E2. J Immunol. 1987; 138(4):1074-81. View

15.

Wolfe L, Coceani F . The role of prostaglandins in the central nervous system. Annu Rev Physiol. 1979; 41:669-84. DOI: 10.1146/annurev.ph.41.030179.003321. View

16.

Passwell J, Dayer J, Merler E . Increased prostaglandin production by human monocytes after membrane receptor activation. J Immunol. 1979; 123(1):115-20. View

17.

Cooper C, Jones H, Weller R, Walker V . Production of prostaglandins and thromboxane by isolated cells from intracranial tumours. J Neurol Neurosurg Psychiatry. 1984; 47(6):579-84. PMC: 1027854. DOI: 10.1136/jnnp.47.6.579. View

18.

Fontana A, Kristensen F, Dubs R, Gemsa D, Weber E . Production of prostaglandin E and an interleukin-1 like factor by cultured astrocytes and C6 glioma cells. J Immunol. 1982; 129(6):2413-9. View

19.

Merchant R, Merchant L, Cook S, McVicar D, Young H . Intralesional infusion of lymphokine-activated killer (LAK) cells and recombinant interleukin-2 (rIL-2) for the treatment of patients with malignant brain tumor. Neurosurgery. 1988; 23(6):725-32. DOI: 10.1227/00006123-198812000-00007. View

20.

Rappaport R, Dodge G . Prostaglandin E inhibits the production of human interleukin 2. J Exp Med. 1982; 155(3):943-8. PMC: 2186623. DOI: 10.1084/jem.155.3.943. View