Interventions for Wound Healing Among Diabetic Patients Infected with Staphylococcus Aureus: a Systematic Review

Overview

Journal Sao Paulo Med J

Specialty General Medicine

Date 2011 Jul 15

PMID 21755251

Citations 4

Authors

Anacassia Fonseca Lima

Livia Bandeira Costa

Joas Lucas da Silva

Maria Bernadete Sousa Maia

Eulalia Camelo Pessoa Azevedo Ximenes

Affiliations

Soon will be listed here.

Abstract

Context And Objective: Staphylococcus aureus is the most frequent agent isolated in diabetic foot infections and may be associated with changes to wound healing times. The aim of this study was to perform a systematic review of the literature, including studies that assessed the efficacy of any clinical or surgical intervention, as well as oral or topical therapy for diabetic ulcers infected with S. aureus.

Design And Setting: Systematic review with a search conducted in databases.

Methods: We conducted a systematic review with a comprehensive search in the Lilacs, SciELO, PubMed/Medline, Old Medline, Embase and Cochrane Library databases, for articles published from 1966 to 2010. The articles selected were limited to studies on diabetic patients with wounds infected with S. aureus for whom their healing was followed up, with the use of either antibiotics or experimental treatments. Animal studies and those that did not report the wound healing, as well as review articles, were excluded.

Results: Five studies that met the inclusion and exclusion criteria were analyzed.

Conclusions: There are few studies reporting the healing of wounds infected with S. aureus in diabetic patients, although this is the most commonly found pathogen in this type of wound and it frequently consists of methicillin-resistant S. aureus (MRSA). There is insufficient evidence to support early use of broad-spectrum antibiotics against MRSA to promote healing of diabetic ulcers, since antibiotic resistance may develop from such treatment. This highlights the need for further studies on the subject.

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