Plasma 25-hydroxyvitamin D is Independently Associated with Hemoglobin Concentration in Male Subjects with Type 2 Diabetes Mellitus

Overview

Journal Int J Endocrinol

Publisher Wiley

Specialty Endocrinology

Date 2011 Jul 15

PMID 21754928

Citations 8

Authors

Shu Meguro

Masuomi Tomita

Takeshi Katsuki

Kiyoe Kato

Henpiru Oh

Akira Ainai

Ryo Ito

Shu Takeda

Toshihide Kawai

Yoshihito Atsumi

Hiroshi Itoh

Hideki Hasegawa

Affiliations

Soon will be listed here.

Abstract

Introduction. It was reported that 25-hydroxyvitamin D level was independently associated with anemia in chronic kidney diseases, but the relation between vitamin D and anemia in diabetes mellitus is not still certain. We analyzed the relation between plasma 25-hydroxyvitamin D level and hemoglobin concentration. Materials and Methods. A cross-sectional study in male patients with type 2 diabetes was performed. Correlation coefficients and standardized partial regression coefficient for the hemoglobin concentration were evaluated. Results. Hemoglobin concentration was positively correlated with body mass index, HbA1c, estimated glomerular filtration rate, cholinesterase, and 25-hydroxyvitamin D level and negatively correlated with age, duration of diabetes mellitus, serum creatinine, and urinary albumin creatinine ratio. Multiple regression analysis revealed the independent relation of 25-hydroxyvitamin D to hemoglobin concentration. Conclusions. Plasma circulating form of vitamin D is significantly associated with hemoglobin concentration in diabetes mellitus independent of the clinical markers for kidney function or nutrition.

Citing Articles

The Role of 25-Hydroxy Vitamin D Deficiency in Iron Deficient Children of North India.

Sharma S, Jain R, Dabla P Indian J Clin Biochem. 2015; 30(3):313-7.

PMID: 26089618 PMC: 4469055. DOI: 10.1007/s12291-014-0449-x.

Effect of paricalcitol vs calcitriol on hemoglobin levels in chronic kidney disease patients: a randomized trial.

Riccio E, Sabbatini M, Bruzzese D, Capuano I, Migliaccio S, Andreucci M PLoS One. 2015; 10(3):e0118174.

PMID: 25781618 PMC: 4363688. DOI: 10.1371/journal.pone.0118174.

Cross-sectional and longitudinal associations between the active vitamin D metabolite (1,25 dihydroxyvitamin D) and haemoglobin levels in older Australian men: the Concord Health and Ageing in Men Project.

Hirani V, Cumming R, Blyth F, Naganathan V, Le Couteur D, Waite L Age (Dordr). 2015; 37(1):9749.

PMID: 25649710 PMC: 4315774. DOI: 10.1007/s11357-015-9749-1.

The effect of vitamin D supplements on the severity of restless legs syndrome.

Wali S, Shukr A, Boudal A, Alsaiari A, Krayem A Sleep Breath. 2014; 19(2):579-83.

PMID: 25148866 DOI: 10.1007/s11325-014-1049-y.

Vitamin D, race, and risk for anemia in children.

Atkinson M, Melamed M, Kumar J, Roy C, Miller 3rd E, Furth S J Pediatr. 2013; 164(1):153-158.e1.

PMID: 24112861 PMC: 3872204. DOI: 10.1016/j.jpeds.2013.08.060.

References

Thomas M, Burns W, Cooper M . Tubular changes in early diabetic nephropathy. Adv Chronic Kidney Dis. 2005; 12(2):177-86. DOI: 10.1053/j.ackd.2005.01.008. View

Saab G, Young D, Gincherman Y, Giles K, Norwood K, Coyne D . Prevalence of vitamin D deficiency and the safety and effectiveness of monthly ergocalciferol in hemodialysis patients. Nephron Clin Pract. 2007; 105(3):c132-8. DOI: 10.1159/000098645. View

Alon D, Chaimovitz C, Dvilansky A, Lugassy G, Douvdevani A, Shany S . Novel role of 1,25(OH)(2)D(3) in induction of erythroid progenitor cell proliferation. Exp Hematol. 2002; 30(5):403-9. DOI: 10.1016/s0301-472x(02)00789-0. View

Tian J, Liu Y, Williams L, de Zeeuw D . Potential role of active vitamin D in retarding the progression of chronic kidney disease. Nephrol Dial Transplant. 2006; 22(2):321-8. DOI: 10.1093/ndt/gfl595. View

Singh D, Winocour P, Summerhayes B, Viljoen A, Sivakumar G, Farrington K . Are low erythropoietin and 1,25-dihydroxyvitamin D levels indicative of tubulo-interstitial dysfunction in diabetes without persistent microalbuminuria?. Diabetes Res Clin Pract. 2009; 85(3):258-64. DOI: 10.1016/j.diabres.2009.06.022. View

Patel N, Gutierrez O, Andress D, Coyne D, Levin A, Wolf M . Vitamin D deficiency and anemia in early chronic kidney disease. Kidney Int. 2010; 77(8):715-20. DOI: 10.1038/ki.2009.551. View

Keane W, Lyle P . Recent advances in management of type 2 diabetes and nephropathy: lessons from the RENAAL study. Am J Kidney Dis. 2003; 41(3 Suppl 1):S22-5. DOI: 10.1053/ajkd.2003.50078. View

Aucella F, Scalzulli R, Gatta G, Vigilante M, Carella A, Stallone C . Calcitriol increases burst-forming unit-erythroid proliferation in chronic renal failure. A synergistic effect with r-HuEpo. Nephron Clin Pract. 2003; 95(4):c121-7. DOI: 10.1159/000074837. View

Kiss Z, Ambrus C, Almasi C, Berta K, Deak G, Horonyi P . Serum 25(OH)-cholecalciferol concentration is associated with hemoglobin level and erythropoietin resistance in patients on maintenance hemodialysis. Nephron Clin Pract. 2010; 117(4):c373-8. DOI: 10.1159/000321521. View

10.

Singh D, Winocour P, Farrington K . Mechanisms of disease: the hypoxic tubular hypothesis of diabetic nephropathy. Nat Clin Pract Nephrol. 2008; 4(4):216-26. DOI: 10.1038/ncpneph0757. View

11.

Bosman D, Winkler A, Marsden J, Macdougall I, Watkins P . Anemia with erythropoietin deficiency occurs early in diabetic nephropathy. Diabetes Care. 2001; 24(3):495-9. DOI: 10.2337/diacare.24.3.495. View

12.

Neves P, Trivino J, Casaubon F, Santos V, Mendes P, Romao P . Elderly patients on chronic hemodialysis with hyperparathyroidism: increase of hemoglobin level after intravenous calcitriol. Int Urol Nephrol. 2006; 38(1):175-7. DOI: 10.1007/s11255-004-1563-0. View

13.

Mathieu C . Vitamin D and diabetes: the devil is in the D-tails. Diabetologia. 2010; 53(8):1545-8. DOI: 10.1007/s00125-010-1791-z. View

14.

Goicoechea M, Vazquez M, Ruiz M, Gomez-Campdera F, Perez-Garcia R, Valderrabano F . Intravenous calcitriol improves anaemia and reduces the need for erythropoietin in haemodialysis patients. Nephron. 1998; 78(1):23-7. DOI: 10.1159/000044877. View

15.

Thomas M, Cooper M, Rossing K, Parving H . Anaemia in diabetes: Is there a rationale to TREAT?. Diabetologia. 2006; 49(6):1151-7. DOI: 10.1007/s00125-006-0215-6. View

16.

Craig K, Williams J, Riley S, Smith H, Owens D, Worthing D . Anemia and diabetes in the absence of nephropathy. Diabetes Care. 2005; 28(5):1118-23. DOI: 10.2337/diacare.28.5.1118. View

17.

Ishimura E, Nishizawa Y, Okuno S, Matsumoto N, Emoto M, Inaba M . Diabetes mellitus increases the severity of anemia in non-dialyzed patients with renal failure. J Nephrol. 1998; 11(2):83-6. View

18.

Nazem A, Mako J . The effect of calcitriol on renal anaemia in patients undergoing long-term dialysis. Int Urol Nephrol. 1997; 29(1):119-27. DOI: 10.1007/BF02551427. View

19.

Matsuo S, Imai E, Horio M, Yasuda Y, Tomita K, Nitta K . Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney Dis. 2009; 53(6):982-92. DOI: 10.1053/j.ajkd.2008.12.034. View

20.

van Etten E, Stoffels K, Gysemans C, Mathieu C, Overbergh L . Regulation of vitamin D homeostasis: implications for the immune system. Nutr Rev. 2008; 66(10 Suppl 2):S125-34. DOI: 10.1111/j.1753-4887.2008.00096.x. View