3-(4-Chloro-benzo-yl)-4-(4-chloro-phen-yl)-1-phenethyl-piperidin-4-ol
Overview
Overview
Authors
Affiliations
Affiliations
Soon will be listed here.
Abstract
In the title compound, C(26)H(25)Cl(2)NO(2), the piperidine ring adopts a chair conformation with a cis configuration of the carbonyl and hy-droxy substituents. The dihedral angle between the aromatic rings of the chloro-benzene groups is 24.3 (2)°. The phenyl ring forms dihedral angles of 59.4 (3) and 44.1 (3)° with the benzene rings. In the crystal, mol-ecules are linked by inter-molecular O-H⋯N and C-H⋯O hydrogen bonds and C-H⋯π inter-actions into layers parallel to the bc plane.
References
1.
Suleyman H, Gul H, Gul M, Alkan M, Gocer F
. Anti-inflammatory activity of bis(3-aryl-3-oxo-propyl)methylamine hydrochloride in rat. Biol Pharm Bull. 2007; 30(1):63-7.
DOI: 10.1248/bpb.30.63.
View
2.
Gul H, Calis U, Vepsalainen J
. Synthesis of some mono-Mannich bases and corresponding azine derivatives and evaluation of their anticonvulsant activity. Arzneimittelforschung. 2004; 54(7):359-64.
DOI: 10.1055/s-0031-1296984.
View
3.
Yogeeswari P, Sriram D, Kavya R, Tiwari S
. Synthesis and in-vitro cytotoxicity evaluation of gatifloxacin Mannich bases. Biomed Pharmacother. 2005; 59(9):501-10.
DOI: 10.1016/j.biopha.2005.06.006.
View
4.
Spek A
. Structure validation in chemical crystallography. Acta Crystallogr D Biol Crystallogr. 2009; 65(Pt 2):148-55.
PMC: 2631630.
DOI: 10.1107/S090744490804362X.
View
5.
Gul H, Ojanen T, Vepsalainen J, Gul M, Erciyas E, Hanninen O
. Antifungal activity of some mono, bis and quaternary Mannich bases derived from acetophenone. Arzneimittelforschung. 2001; 51(1):72-5.
DOI: 10.1055/s-0031-1300005.
View