Enteroviral Infection in End Stage Dilated Cardiomyopathy

Overview

Journal Klin Wochenschr

Specialty General Medicine

Date 1990 Sep 14

PMID 2175375

Citations 5

Authors

V Wiegand

S Tracy

N Chapman

C Wucherpfennig

Affiliations

Soon will be listed here.

Abstract

In order to evaluate the role of enteroviral infections in end stage dilated cardiomyopathy, RNA was isolated from left ventricular myocardium of patients with dilated cardiomyopathy explanted during heart transplantation (n = 6) and from control hearts (n = 8), then probed using a dot blot procedure with two well-defined enteroviral cloned cDNA probes. One of the cardiomyopathic heart samples hybridized with the enteroviral probes, while RNA samples from the other diseased heart and the control heart demonstrated no hybridization. To verify further the enteroviral infection, a cDNA prepared from the positive heart RNA hybridized with Southern blotted coxsackievirus B3 and poliovirus 1 nucleotide sequences, while a control sample, which gave negative results in the dot blot, showed no hybridization to the enteroviral sequence. These results provide evidence for an enteroviral infection in certain patients with end stage dilated cardiomyopathy.

Citing Articles

Persistent Enterovirus Infection: Little Deletions, Long Infections.

Chapman N Vaccines (Basel). 2022; 10(5).

PMID: 35632526 PMC: 9143164. DOI: 10.3390/vaccines10050770.

Molecular evaluation of enteroviruses in the pathogenesis of idiopathic dilated cardiomyopathy.

Jeffery S, Kelling P, Lukaszyk A, Boriskin Y, BOOTH J, Hodgson J Clin Cardiol. 1997; 20(10):857-63.

PMID: 9377822 PMC: 6655876. DOI: 10.1002/clc.4960201012.

Link between enteroviruses and dilated cardiomyopathy: serological and molecular data.

Keeling P, Tracy S Br Heart J. 1994; 72(6 Suppl):S25-9.

PMID: 7873321 PMC: 1025673. DOI: 10.1136/hrt.72.6_suppl.s25.

Detection of enteroviruses in cell cultures by using in situ transcription.

Carstens J, Tracy S, Chapman N, Gauntt C J Clin Microbiol. 1992; 30(1):25-35.

PMID: 1370849 PMC: 264991. DOI: 10.1128/jcm.30.1.25-35.1992.

Coxsackievirus B3 from an infectious cDNA copy of the genome is cardiovirulent in mice.

Tracy S, Chapman N, Tu Z Arch Virol. 1992; 122(3-4):399-409.

PMID: 1310000 DOI: 10.1007/BF01317202.

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