Language Impairment and Right Hemiparesis in a 54-year-old Woman

Overview

Journal Front Neurol

Specialty Neurology

Date 2011 Jul 13

PMID 21747776

Authors

Alexander Venizelos

John Lee

Jose Biller

Affiliations

Soon will be listed here.

Abstract

A 54-year-old woman presented to the emergency room with 3 months of slurred speech, language problems, and right hemiparesis. Initial impression based on history, exam, and imaging was brain abscess vs. primary or metastatic neoplasm. Brain biopsy of the lesion and pathologic specimens were obtained. Below is a description of her presentation, hospital course, imaging, and pathology, as well as a short discussion of the final diagnosis.

References

Kimiskidis V, Sakellari I, Tsimourtou V, Kapina V, Papagiannopoulos S, Kazis D . Autologous stem-cell transplantation in malignant multiple sclerosis: a case with a favorable long-term outcome. Mult Scler. 2007; 14(2):278-83. DOI: 10.1177/1352458507082604. View

Selkirk S, Shi J . Relapsing-remitting tumefactive multiple sclerosis. Mult Scler. 2005; 11(6):731-4. DOI: 10.1191/1352458505ms1214cr. View

Jeffery D, Lefkowitz D, Crittenden J . Treatment of Marburg variant multiple sclerosis with mitoxantrone. J Neuroimaging. 2004; 14(1):58-62. View

Hu W, Lucchinetti C . The pathological spectrum of CNS inflammatory demyelinating diseases. Semin Immunopathol. 2009; 31(4):439-53. DOI: 10.1007/s00281-009-0178-z. View

Lacour A, De Seze J, Revenco E, Lebrun C, Masmoudi K, Vidry E . Acute aphasia in multiple sclerosis: A multicenter study of 22 patients. Neurology. 2004; 62(6):974-7. DOI: 10.1212/01.wnl.0000115169.23421.5d. View

Leussink V, Lehmann H, Meyer Zu Horste G, Hartung H, Stuve O, Kieseier B . Rituximab induces clinical stabilization in a patient with fulminant multiple sclerosis not responding to natalizumab. Evidence for disease heterogeneity. J Neurol. 2008; 255(9):1436-8. DOI: 10.1007/s00415-008-0956-x. View

Nilsson P, Larsson E, Kahlon B, Nordstrom C, Norrving B . Tumefactive demyelinating disease treated with decompressive craniectomy. Eur J Neurol. 2009; 16(5):639-42. DOI: 10.1111/j.1468-1331.2009.02547.x. View

Lucchinetti C, Gavrilova R, Metz I, Parisi J, Scheithauer B, Weigand S . Clinical and radiographic spectrum of pathologically confirmed tumefactive multiple sclerosis. Brain. 2008; 131(Pt 7):1759-75. PMC: 2442427. DOI: 10.1093/brain/awn098. View

Kiriyama T, Kataoka H, Taoka T, Tonomura Y, Terashima M, Morikawa M . Characteristic neuroimaging in patients with tumefactive demyelinating lesions exceeding 30 mm. J Neuroimaging. 2010; 21(2):e69-77. DOI: 10.1111/j.1552-6569.2010.00502.x. View

10.

Pittock S, McClelland R, Achenbach S, Konig F, Bitsch A, Bruck W . Clinical course, pathological correlations, and outcome of biopsy proved inflammatory demyelinating disease. J Neurol Neurosurg Psychiatry. 2005; 76(12):1693-7. PMC: 1739469. DOI: 10.1136/jnnp.2004.060624. View