Anti-inflammatory Effects of Chinese Medicinal Herbs on Cerebral Ischemia

Overview

Journal Chin Med

Publisher Biomed Central

Specialty Biomedical Engineering

Date 2011 Jul 12

PMID 21740583

Citations 10

Authors

Shan-Yu Su

Ching-Liang Hsieh

Affiliations

Soon will be listed here.

Abstract

Recent studies have demonstrated the importance of anti-inflammation, including cellular immunity, inflammatory mediators, reactive oxygen species, nitric oxide and several transcriptional factors, in the treatment of cerebral ischemia. This article reviews the roles of Chinese medicinal herbs as well as their ingredients in the inflammatory cascade induced by cerebral ischemia. Chinese medicinal herbs exert neuroprotective effects on cerebral ischemia. The effects include inhibiting the activation of microglia, decreasing levels of adhesion molecules such as intracellular adhesion molecule-1, attenuating expression of pro-inflammatory cytokines such as interleukin-1β and tumor necrosis factor-α, reducing inducible nitric oxide synthase and reactive oxygen species, and regulating transcription factors such as nuclear factor-κB.

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