Mucocutaneous Leishmaniasis: Clinical Markers in Presumptive Diagnosis

Overview

Journal Braz J Otorhinolaryngol

Specialty Otorhinolaryngology

Date 2011 Jul 9

PMID 21739015

Citations 16

Authors

Joao Luiz Cioglia Pereira Diniz

Manoel Otavio da Rocha Costa

Denise Utsch Goncalves

Affiliations

Soon will be listed here.

Abstract

Unlabelled: Mucocutaneous Leishmaniasis (ML) can lead to serious sequela; however, early diagnosis can prevent complications.

Aim: To evaluate clinical markers for the early diagnosis of ML.

Materials And Methods: A series study of 21 cases of ML, which were evaluated through clinical interview, nasal endoscopy, biopsy and the Montenegro test.

Results: A skin scar and previous diagnosis of cutaneous leishmaniasis (CL) were reported in 8(38%) patients, and 13(62%) of them denied having had previous CL and had no scar. Nasal/oral symptom onset until the ML diagnosis varied from 5 months to 20 years, mean value of 6 years. In the Montenegro test, the average size of the papule was 14.5 mm, which did not correlate with disease duration (p=0.87). The nose was the most often involved site and the extension of the injured mucosa did not correlate with disease duration. The parasite was found in 2 (9.52%) biopsy specimens.

Conclusions: ML diagnosis was late. Finding the parasite in the mucosa, cutaneous scar and/or previous diagnosis of CL were not clinical markers for ML. ML diagnosis must be based on the Montenegro test, chronic nasal and/or oral discharge and histological findings ruling out other granulomatous diseases.

Citing Articles

Comparison of the spatial and temporal distribution of cutaneous and mucosal leishmaniasis in the state of Rio de Janeiro between 2001 and 2011.

Paes L, Oliveira R, Magalhaes M, Pimentel M, Lyra M, Carvalho-Paes L PLoS One. 2024; 19(12):e0308298.

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Understanding American tegumentary leishmaniasis in urban Montes Claros, Brazil: insights from clinical, immunological and therapeutic investigations.

Lopes D, Lima J, Ribeiro K, Gomes C, Rocha R, Goncalves T Parasitology. 2024; 151(11):1260-1268.

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Temporal patterns, spatial risks, and characteristics of tegumentary leishmaniasis in Brazil in the first twenty years of the 21st Century.

Belo V, Bruhn F, Barbosa D, Camara D, Simoes T, Buzanovsky L PLoS Negl Trop Dis. 2023; 17(6):e0011405.

PMID: 37285388 PMC: 10281579. DOI: 10.1371/journal.pntd.0011405.

Leishmania RNA virus-1 is similarly detected among metastatic and non-metastatic phenotypes in a prospective cohort of American Tegumentary Leishmaniasis.

Valencia B, Lau R, Kariyawasam R, Jara M, Ramos A, Chantry M PLoS Negl Trop Dis. 2022; 16(1):e0010162.

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Development of a chimeric protein based on a proteomic approach for the serological diagnosis of human tegumentary leishmaniasis.

Garcia G, Carvalho A, Duarte M, Costa E Silva M, Medeiros F, Ferraz Coelho E Appl Microbiol Biotechnol. 2021; 105(18):6805-6817.

PMID: 34432132 DOI: 10.1007/s00253-021-11518-1.

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