The Prediabetic Period: Review of Clinical Aspects

Overview

Journal Diabetes Metab J

Specialty Endocrinology

Date 2011 Jul 9

PMID 21738892

Citations 36

Authors

Sang Youl Rhee

Jeong-Taek Woo

Affiliations

Soon will be listed here.

Abstract

Hyperglycemia that does not satisfy the diagnostic criteria for diabetes mellitus (DM) is generally called prediabetes (preDM). The global prevalence of preDM has been increasing progressively in the past few decades, and it has been established that preDM status is a strong risk factor for DM and cardiovascular disease. Currently, preDM status is classified into two subtypes: impaired fasting glucose and impaired glucose tolerance. Currently, preDM is not regarded as an independent clinical entity, but only as a risk factor for others. In this article, we review various clinical aspects of preDM in terms of the working definition, changes in criteria over the years, epidemiology, and pathophysiological characteristics, and its clinical significance in current medicine.

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References

. International Expert Committee report on the role of the A1C assay in the diagnosis of diabetes. Diabetes Care. 2009; 32(7):1327-34. PMC: 2699715. DOI: 10.2337/dc09-9033. View

. Glucose tolerance and mortality: comparison of WHO and American Diabetes Association diagnostic criteria. The DECODE study group. European Diabetes Epidemiology Group. Diabetes Epidemiology: Collaborative analysis Of Diagnostic criteria in Europe. Lancet. 1999; 354(9179):617-21. View

de Vegt F, Dekker J, Stehouwer C, Nijpels G, Bouter L, Heine R . The 1997 American Diabetes Association criteria versus the 1985 World Health Organization criteria for the diagnosis of abnormal glucose tolerance: poor agreement in the Hoorn Study. Diabetes Care. 1998; 21(10):1686-90. DOI: 10.2337/diacare.21.10.1686. View

de Vegt F, Dekker J, Jager A, Hienkens E, Kostense P, Stehouwer C . Relation of impaired fasting and postload glucose with incident type 2 diabetes in a Dutch population: The Hoorn Study. JAMA. 2001; 285(16):2109-13. DOI: 10.1001/jama.285.16.2109. View

Weykamp C, John W, Mosca A, Hoshino T, Little R, Jeppsson J . The IFCC Reference Measurement System for HbA1c: a 6-year progress report. Clin Chem. 2008; 54(2):240-8. DOI: 10.1373/clinchem.2007.097402. View

Qiao Q, Hu G, Tuomilehto J, Nakagami T, Balkau B, Borch-Johnsen K . Age- and sex-specific prevalence of diabetes and impaired glucose regulation in 11 Asian cohorts. Diabetes Care. 2003; 26(6):1770-80. DOI: 10.2337/diacare.26.6.1770. View

Hanley A, Williams K, Gonzalez C, DAgostino Jr R, Wagenknecht L, Stern M . Prediction of type 2 diabetes using simple measures of insulin resistance: combined results from the San Antonio Heart Study, the Mexico City Diabetes Study, and the Insulin Resistance Atherosclerosis Study. Diabetes. 2003; 52(2):463-9. DOI: 10.2337/diabetes.52.2.463. View

Shaw J, Zimmet P, de Courten M, Dowse G, Chitson P, Gareeboo H . Impaired fasting glucose or impaired glucose tolerance. What best predicts future diabetes in Mauritius?. Diabetes Care. 1999; 22(3):399-402. DOI: 10.2337/diacare.22.3.399. View

Levitan E, Song Y, Ford E, Liu S . Is nondiabetic hyperglycemia a risk factor for cardiovascular disease? A meta-analysis of prospective studies. Arch Intern Med. 2004; 164(19):2147-55. DOI: 10.1001/archinte.164.19.2147. View

10.

Abdul-Ghani M, Jenkinson C, Richardson D, Tripathy D, DeFronzo R . Insulin secretion and action in subjects with impaired fasting glucose and impaired glucose tolerance: results from the Veterans Administration Genetic Epidemiology Study. Diabetes. 2006; 55(5):1430-5. DOI: 10.2337/db05-1200. View

11.

Faerch K, Vaag A, Holst J, Hansen T, Jorgensen T, Borch-Johnsen K . Natural history of insulin sensitivity and insulin secretion in the progression from normal glucose tolerance to impaired fasting glycemia and impaired glucose tolerance: the Inter99 study. Diabetes Care. 2008; 32(3):439-44. PMC: 2646025. DOI: 10.2337/dc08-1195. View

12.

Unwin N, Gan D, Whiting D . The IDF Diabetes Atlas: providing evidence, raising awareness and promoting action. Diabetes Res Clin Pract. 2009; 87(1):2-3. DOI: 10.1016/j.diabres.2009.11.006. View

13.

Schmidt M, Duncan B, Bang H, Pankow J, Ballantyne C, Golden S . Identifying individuals at high risk for diabetes: The Atherosclerosis Risk in Communities study. Diabetes Care. 2005; 28(8):2013-8. DOI: 10.2337/diacare.28.8.2013. View

14.

Tominaga M, Makino H, Yoshino G, Kuwa K, Takei I, Aono Y . Japanese standard reference material for JDS Lot 2 haemoglobin A1c. I: Comparison of Japan Diabetes Society-assigned values to those obtained by the Japanese and USA domestic standardization programmes and by the International Federation of Clinical.... Ann Clin Biochem. 2005; 42(Pt 1):41-6. DOI: 10.1258/0004563053026835. View

15.

Borch-Johnsen K, Colagiuri S, Balkau B, Glumer C, Carstensen B, Ramachandran A . Creating a pandemic of prediabetes: the proposed new diagnostic criteria for impaired fasting glycaemia. Diabetologia. 2004; 47(8):1396-402. DOI: 10.1007/s00125-004-1468-6. View

16.

Cowie C, Rust K, Ford E, Eberhardt M, Byrd-Holt D, Li C . Full accounting of diabetes and pre-diabetes in the U.S. population in 1988-1994 and 2005-2006. Diabetes Care. 2008; 32(2):287-94. PMC: 2628695. DOI: 10.2337/dc08-1296. View

17.

Abdul-Ghani M, DeFronzo R . Pathophysiology of prediabetes. Curr Diab Rep. 2009; 9(3):193-9. DOI: 10.1007/s11892-009-0032-7. View

18.

Bennett C, Guo M, Dharmage S . HbA(1c) as a screening tool for detection of Type 2 diabetes: a systematic review. Diabet Med. 2007; 24(4):333-43. DOI: 10.1111/j.1464-5491.2007.02106.x. View

19.

Ford E, Zhao G, Li C . Pre-diabetes and the risk for cardiovascular disease: a systematic review of the evidence. J Am Coll Cardiol. 2010; 55(13):1310-7. DOI: 10.1016/j.jacc.2009.10.060. View

20.

Wong T, Liew G, Tapp R, Schmidt M, Wang J, Mitchell P . Relation between fasting glucose and retinopathy for diagnosis of diabetes: three population-based cross-sectional studies. Lancet. 2008; 371(9614):736-43. PMC: 2350208. DOI: 10.1016/S0140-6736(08)60343-8. View