Preserving Charge and Oxidation State of Au(III) Ions in an Agent-functionalized Nanocrystal Model System

Overview

Journal ACS Nano

Publisher American Chemical Society

Specialty Biotechnology

Date 2011 Jul 9

PMID 21736315

Citations 5

Authors

Stefan Mullegger

Wolfgang Schofberger

Mohammad Rashidi

Thomas Lengauer

Florian Klappenberger

Katharina Diller

Kamuran Kara

Johannes V Barth

Eva Rauls

Wolf Gero Schmidt

Reinhold Koch

Affiliations

Soon will be listed here.

Abstract

Supporting functional molecules on crystal facets is an established technique in nanotechnology. To preserve the original activity of ionic metallorganic agents on a supporting template, conservation of the charge and oxidation state of the active center is indispensable. We present a model system of a metallorganic agent that, indeed, fulfills this design criterion on a technologically relevant metal support with potential impact on Au(III)-porphyrin-functionalized nanoparticles for an improved anticancer-drug delivery. Employing scanning tunneling microscopy and -spectroscopy in combination with photoemission spectroscopy, we clarify at the single-molecule level the underlying mechanisms of this exceptional adsorption mode. It is based on the balance between a high-energy oxidation state and an electrostatic screening-response of the surface (image charge). Modeling with first principles methods reveals submolecular details of the metal-ligand bonding interaction and completes the study by providing an illustrative electrostatic model relevant for ionic metalorganic agent molecules, in general.

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