Hippocampal Sclerosis in Children Younger Than 2 Years

Overview

Journal Pediatr Radiol

Specialty Pediatrics

Date 2011 Jul 8

PMID 21735179

Citations 3

Authors

Nadja Kadom

Tammy Tsuchida

William D Gaillard

Affiliations

Soon will be listed here.

Abstract

Background: Hippocampal sclerosis (HS) is rarely considered as a diagnosis in children younger than 2 years.

Objective: To describe imaging features in conjunction with clinical information in patients with hippocampal sclerosis who are younger than 2 years.

Materials And Methods: We retrospectively reviewed MR brain imaging and clinical information in five children in whom the diagnosis of HS was made both clinically and by MRI prior to 2 years of age.

Results: Imaging features establishing the diagnosis of hippocampal sclerosis were bright T2 signal and volume loss, while the internal architecture of the hippocampal formation was preserved in almost all children. Clinically, all children had an infectious trigger.

Conclusion: It is necessary for radiologists to consider HS in children with certain clinical features to plan an MRI protocol that is appropriate for detection of hippocampal pathology.

Citing Articles

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Comments on hippocampal sclerosis in children younger than 2 years.

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References

Mohamed A, Wyllie E, Ruggieri P, Kotagal P, Babb T, Hilbig A . Temporal lobe epilepsy due to hippocampal sclerosis in pediatric candidates for epilepsy surgery. Neurology. 2001; 56(12):1643-9. DOI: 10.1212/wnl.56.12.1643. View

Bronen R . MR of mesial temporal sclerosis: how much is enough?. AJNR Am J Neuroradiol. 1998; 19(1):15-8. PMC: 8337351. View

Wiebe S, Blume W, Girvin J, Eliasziw M . A randomized, controlled trial of surgery for temporal-lobe epilepsy. N Engl J Med. 2001; 345(5):311-8. DOI: 10.1056/NEJM200108023450501. View

Scott R . Status epilepticus in the developing brain: Long-term effects seen in humans. Epilepsia. 2009; 50 Suppl 12:32-3. DOI: 10.1111/j.1528-1167.2009.02374.x. View

Theodore W, Kelley K, Toczek M, Gaillard W . Epilepsy duration, febrile seizures, and cerebral glucose metabolism. Epilepsia. 2004; 45(3):276-9. DOI: 10.1111/j.0013-9580.2004.51803.x. View

Phal P, Usmanov A, Nesbit G, Anderson J, Spencer D, Wang P . Qualitative comparison of 3-T and 1.5-T MRI in the evaluation of epilepsy. AJR Am J Roentgenol. 2008; 191(3):890-5. DOI: 10.2214/AJR.07.3933. View

French J, Williamson P, Thadani V, Darcey T, Mattson R, Spencer S . Characteristics of medial temporal lobe epilepsy: I. Results of history and physical examination. Ann Neurol. 1993; 34(6):774-80. DOI: 10.1002/ana.410340604. View

Prudent V, Kumar A, Liu S, Wiggins G, Malaspina D, Gonen O . Human hippocampal subfields in young adults at 7.0 T: feasibility of imaging. Radiology. 2010; 254(3):900-6. PMC: 2826699. DOI: 10.1148/radiol.09090897. View

Gaillard W, Chiron C, Cross J, Harvey A, Kuzniecky R, Hertz-Pannier L . Guidelines for imaging infants and children with recent-onset epilepsy. Epilepsia. 2009; 50(9):2147-53. DOI: 10.1111/j.1528-1167.2009.02075.x. View

10.

Grattan-Smith J, Harvey A, Desmond P, Chow C . Hippocampal sclerosis in children with intractable temporal lobe epilepsy: detection with MR imaging. AJR Am J Roentgenol. 1993; 161(5):1045-8. DOI: 10.2214/ajr.161.5.8273606. View

11.

Bronen R . Epilepsy: the role of MR imaging. AJR Am J Roentgenol. 1992; 159(6):1165-74. DOI: 10.2214/ajr.159.6.1442376. View

12.

Mathern G, Adelson P, Cahan L, Leite J . Hippocampal neuron damage in human epilepsy: Meyer's hypothesis revisited. Prog Brain Res. 2002; 135:237-51. DOI: 10.1016/s0079-6123(02)35023-4. View

13.

King K, Glodzik L, Liu S, Babb J, de Leon M, Gonen O . Anteroposterior hippocampal metabolic heterogeneity: three-dimensional multivoxel proton 1H MR spectroscopic imaging--initial findings. Radiology. 2008; 249(1):242-50. PMC: 2657854. DOI: 10.1148/radiol.2491071500. View

14.

Dunleavy M, Shinoda S, Schindler C, Ewart C, Dolan R, Gobbo O . Experimental neonatal status epilepticus and the development of temporal lobe epilepsy with unilateral hippocampal sclerosis. Am J Pathol. 2009; 176(1):330-42. PMC: 2797894. DOI: 10.2353/ajpath.2010.090119. View

15.

Tellez-Zenteno J, Dhar R, Wiebe S . Long-term seizure outcomes following epilepsy surgery: a systematic review and meta-analysis. Brain. 2005; 128(Pt 5):1188-98. DOI: 10.1093/brain/awh449. View

16.

Stanley J, Cendes F, Dubeau F, Andermann F, Arnold D . Proton magnetic resonance spectroscopic imaging in patients with extratemporal epilepsy. Epilepsia. 1998; 39(3):267-73. DOI: 10.1111/j.1528-1157.1998.tb01371.x. View

17.

Scott R, King M, Gadian D, Neville B, Connelly A . Hippocampal abnormalities after prolonged febrile convulsion: a longitudinal MRI study. Brain. 2003; 126(Pt 11):2551-7. DOI: 10.1093/brain/awg262. View

18.

VanLandingham K, Heinz E, Cavazos J, Lewis D . Magnetic resonance imaging evidence of hippocampal injury after prolonged focal febrile convulsions. Ann Neurol. 1998; 43(4):413-26. DOI: 10.1002/ana.410430403. View

19.

Chan S, Erickson J, Yoon S . Limbic system abnormalities associated with mesial temporal sclerosis: a model of chronic cerebral changes due to seizures. Radiographics. 1997; 17(5):1095-110. DOI: 10.1148/radiographics.17.5.9308104. View

20.

Harvey A, Cross J, Shinnar S, Mathern G, Mathern B . Defining the spectrum of international practice in pediatric epilepsy surgery patients. Epilepsia. 2007; 49(1):146-55. DOI: 10.1111/j.1528-1167.2007.01421.x. View