Is Hyperhomocysteinemia Relevant in Patients with Celiac Disease?

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2011 Jul 8

PMID 21734805

Citations 5

Authors

Giovanni Casella

Gabrio Bassotti

Vincenzo Villanacci

Camillo Di Bella

Fabio Pagni

Gian Luigi Corti

Giuseppe Sabatino

Mara Piatti

Vittorio Baldini

Affiliations

Soon will be listed here.

Abstract

Aim: To investigate whether this might be related to the presence of hyperhomocysteinemia.

Methods: From January 1998 to December 2008, we evaluated the presence of hyperhomocysteinemia in a series of 165 adult celiac disease (CD) patients (138 females and 27 males, mean age 43 years).

Results: Hyperhomocysteinemia was evident in 32 patients (19.3%), although most of them had moderate levels (mean value 25 mcg/ml; range 15-30). Only one patient had a history of myocardial infarction (heterozygosis for N5-N10-metil tetrahydrofolate reductase mutation).

Conclusion: The systematic assessment of hyperhomocysteinemia seems, at present, unjustified in CD patients.

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