Unusual Central Nervous System Lesions in Slaughter-weight Pigs with Porcine Circovirus Type 2 Systemic Infection

Overview

Journal Can Vet J

Specialty Veterinary Medicine

Date 2011 Jul 7

PMID 21731092

Citations 1

Authors

Richard Drolet

Francois Cardinal

Alain Houde

Carl A Gagnon

Affiliations

Soon will be listed here.

Abstract

Porcine circovirus type 2 systemic infection was diagnosed in 2 slaughter-weight pigs based on postmortem examination. The infection was associated with unusual central nervous system lesions characterized by a multifocal lymphohistiocytic to granulomatous meningoencephalomyelitis with giant cell formation. The role of these nervous system lesions in the development of the clinical signs in these pigs remains uncertain.

Citing Articles

Non-ambulatory pigs in two Brazilian growing-finishing farms: a clinic, etiological and pathological perspective on 76 cases.

Piva M, Schwertz C, Henker L, Bianchi R, Kemper R, de Almeida B Porcine Health Manag. 2022; 8(1):36.

PMID: 35948945 PMC: 9364575. DOI: 10.1186/s40813-022-00279-6.

References

Magar R, Larochelle R, Thibault S, Lamontagne L . Experimental transmission of porcine circovirus type 2 (PCV2) in weaned pigs: a sequential study. J Comp Pathol. 2000; 123(4):258-69. DOI: 10.1053/jcpa.2000.0413. View

Rosell C, Segales J, Plana-Duran J, Balasch M, Rodriguez-Arrioja G, Kennedy S . Pathological, immunohistochemical, and in-situ hybridization studies of natural cases of postweaning multisystemic wasting syndrome (PMWS) in pigs. J Comp Pathol. 1999; 120(1):59-78. DOI: 10.1053/jcpa.1998.0258. View

Correa A, Zlotowski P, de Barcellos D, da Cruz C, Driemeier D . Brain lesions in pigs affected with postweaning multisystemic wasting syndrome. J Vet Diagn Invest. 2007; 19(1):109-12. DOI: 10.1177/104063870701900120. View

Vanderhallen H, Koenen F . Rapid diagnosis of encephalomyocarditis virus infections in pigs using a reverse transcription-polymerase chain reaction. J Virol Methods. 1997; 66(1):83-9. DOI: 10.1016/s0166-0934(97)02214-3. View

Chen Q, Li J, Deng Z, Xiong W, Wang Q, Hu Y . Comprehensive detection and identification of seven animal coronaviruses and human respiratory coronavirus 229E with a microarray hybridization assay. Intervirology. 2009; 53(2):95-104. PMC: 7179550. DOI: 10.1159/000264199. View

Gagnon C, Music N, Fontaine G, Tremblay D, Harel J . Emergence of a new type of porcine circovirus in swine (PCV): a type 1 and type 2 PCV recombinant. Vet Microbiol. 2010; 144(1-2):18-23. DOI: 10.1016/j.vetmic.2009.09.072. View

Opriessnig T, Meng X, Halbur P . Porcine circovirus type 2 associated disease: update on current terminology, clinical manifestations, pathogenesis, diagnosis, and intervention strategies. J Vet Diagn Invest. 2007; 19(6):591-615. DOI: 10.1177/104063870701900601. View

Carman S, Cai H, DeLay J, Youssef S, McEwen B, Gagnon C . The emergence of a new strain of porcine circovirus-2 in Ontario and Quebec swine and its association with severe porcine circovirus associated disease--2004-2006. Can J Vet Res. 2008; 72(3):259-68. PMC: 2327251. View

Olvera A, Sibila M, Calsamiglia M, Segales J, Domingo M . Comparison of porcine circovirus type 2 load in serum quantified by a real time PCR in postweaning multisystemic wasting syndrome and porcine dermatitis and nephropathy syndrome naturally affected pigs. J Virol Methods. 2004; 117(1):75-80. DOI: 10.1016/j.jviromet.2003.12.007. View

10.

Gagnon C, Tremblay D, Tijssen P, Venne M, Houde A, Elahi S . The emergence of porcine circovirus 2b genotype (PCV-2b) in swine in Canada. Can Vet J. 2007; 48(8):811-9. PMC: 1914312. View

11.

Brunborg I, Moldal T, Jonassen C . Quantitation of porcine circovirus type 2 isolated from serum/plasma and tissue samples of healthy pigs and pigs with postweaning multisystemic wasting syndrome using a TaqMan-based real-time PCR. J Virol Methods. 2004; 122(2):171-8. DOI: 10.1016/j.jviromet.2004.08.014. View

12.

Gagnon C, Spearman G, Hamel A, Godson D, Fortin A, Fontaine G . Characterization of a Canadian mink H3N2 influenza A virus isolate genetically related to triple reassortant swine influenza virus. J Clin Microbiol. 2009; 47(3):796-9. PMC: 2650907. DOI: 10.1128/JCM.01228-08. View

13.

Seeliger F, Brugmann M, Kruger L, Greiser-Wilke I, Verspohl J, Segales J . Porcine circovirus type 2-associated cerebellar vasculitis in postweaning multisystemic wasting syndrome (PMWS)-affected pigs. Vet Pathol. 2007; 44(5):621-34. DOI: 10.1354/vp.44-5-621. View

14.

Segales J, Allan G, Domingo M . Porcine circovirus diseases. Anim Health Res Rev. 2006; 6(2):119-42. DOI: 10.1079/ahr2005106. View

15.

Gagnon C, Del Castillo J, Music N, Fontaine G, Harel J, Tremblay D . Development and use of a multiplex real-time quantitative polymerase chain reaction assay for detection and differentiation of Porcine circovirus-2 genotypes 2a and 2b in an epidemiological survey. J Vet Diagn Invest. 2008; 20(5):545-58. DOI: 10.1177/104063870802000503. View