Polypharmacy, Multiple Natural Health Products and Hepatotoxicity

Overview

Journal CMAJ

Date 2011 Jul 6

PMID 21727224

Citations 4

Authors

Kosta Cvijovic

Heather Boon

Walter Jaeger

Sunita Vohra

Affiliations

Soon will be listed here.

Citing Articles

Becoming a 'pharmaceutical person': Medication use trajectories from age 26 to 38 in a representative birth cohort from Dunedin, New Zealand.

Ballantyne P, Norris P, Parachuru V, Thomson W SSM Popul Health. 2018; 4:37-44.

PMID: 29349271 PMC: 5769117. DOI: 10.1016/j.ssmph.2017.11.002.

Pharmacy study of natural health product adverse reactions (SONAR): a cross-sectional study using active surveillance in community pharmacies to detect adverse events associated with natural health products and assess causality.

Necyk C, Tsuyuki R, Boon H, Foster B, Legatt D, Cembrowski G BMJ Open. 2014; 4(3):e003431.

PMID: 24682573 PMC: 3975764. DOI: 10.1136/bmjopen-2013-003431.

Polypharmacy meets polyherbacy: pharmaceutical, over-the-counter, and natural health product use among Canadian adults.

Votova K, Blais R, Penning M, Maclure M Can J Public Health. 2013; 104(3):e222-8.

PMID: 23823886 PMC: 6973783. DOI: 10.17269/cjph.104.3695.

Study of natural health product adverse reactions (SONAR): active surveillance of adverse events following concurrent natural health product and prescription drug use in community pharmacies.

Vohra S, Cvijovic K, Boon H, Foster B, Jaeger W, Legatt D PLoS One. 2012; 7(9):e45196.

PMID: 23028841 PMC: 3461007. DOI: 10.1371/journal.pone.0045196.

References

Naranjo C, Busto U, Sellers E, Sandor P, Ruiz I, Roberts E . A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981; 30(2):239-45. DOI: 10.1038/clpt.1981.154. View

Smith J, SEIDL L, Cluff L . Studies on the epidemiology of adverse drug reactions. V. Clinical factors influencing susceptibility. Ann Intern Med. 1966; 65(4):629-40. DOI: 10.7326/0003-4819-65-4-629. View

Carvajal A, Begaud B, Moride Y, Vega T, Arias L . Under-reporting of adverse drug reactions. Estimate based on a spontaneous reporting scheme and a sentinel system. Eur J Clin Pharmacol. 1998; 54(6):483-8. DOI: 10.1007/s002280050498. View

Sencan I, Sahin I, Ozcetin A . Low-dose venlafaxine-associated liver toxicity in chronic hepatitis. Ann Pharmacother. 2004; 38(2):352-3. DOI: 10.1345/aph.1D205. View

Leo M, Lieber C . Alcohol, vitamin A, and beta-carotene: adverse interactions, including hepatotoxicity and carcinogenicity. Am J Clin Nutr. 1999; 69(6):1071-85. DOI: 10.1093/ajcn/69.6.1071. View

Horsmans Y, De Clercq M, Sempoux C . Venlafaxine-associated hepatitis. Ann Intern Med. 1999; 130(11):944. DOI: 10.7326/0003-4819-130-11-199906010-00014. View

Fallon M, Boyer J . Hepatic toxicity of vitamin A and synthetic retinoids. J Gastroenterol Hepatol. 1990; 5(3):334-42. DOI: 10.1111/j.1440-1746.1990.tb01635.x. View

Leekumjorn S, Wu Y, Sum A, Chan C . Experimental and computational studies investigating trehalose protection of HepG2 cells from palmitate-induced toxicity. Biophys J. 2007; 94(7):2869-83. PMC: 2267146. DOI: 10.1529/biophysj.107.120717. View

Hamid S, Rojter S, Vierling J . Protracted cholestatic hepatitis after the use of prostata. Ann Intern Med. 1997; 127(2):169-70. DOI: 10.7326/0003-4819-127-2-199707150-00033. View

10.

Ritskes-Hoitinga J, Verschuren P, Meijer G, Wiersma A, van de Kooij A, Timmer W . The association of increasing dietary concentrations of fish oil with hepatotoxic effects and a higher degree of aorta atherosclerosis in the ad lib.-fed rabbit. Food Chem Toxicol. 1998; 36(8):663-72. DOI: 10.1016/s0278-6915(98)00028-3. View

11.

Franck A, Sliter L . Acute hepatic injury associated with varenicline in a patient with underlying liver disease. Ann Pharmacother. 2009; 43(9):1539-43. DOI: 10.1345/aph.1M131. View

12.

Bailey D, Dresser G . Natural products and adverse drug interactions. CMAJ. 2004; 170(10):1531-2. PMC: 400713. DOI: 10.1503/cmaj.1031558. View

13.

Horn J, Hansten P, Chan L . Proposal for a new tool to evaluate drug interaction cases. Ann Pharmacother. 2007; 41(4):674-80. DOI: 10.1345/aph.1H423. View

14.

Rauen U, Klempt S, De Groot H . Histidine-induced injury to cultured liver cells, effects of histidine derivatives and of iron chelators. Cell Mol Life Sci. 2006; 64(2):192-205. PMC: 11136307. DOI: 10.1007/s00018-006-6456-1. View

15.

Garlick P . The nature of human hazards associated with excessive intake of amino acids. J Nutr. 2004; 134(6 Suppl):1633S-1639S. DOI: 10.1093/jn/134.6.1633S. View

16.

Scarna A, Gijsman H, McTavish S, Harmer C, Cowen P, Goodwin G . Effects of a branched-chain amino acid drink in mania. Br J Psychiatry. 2003; 182:210-3. DOI: 10.1192/bjp.182.3.210. View

17.

Ramos R, Mascarenhas J, Duarte P, Vicente C, Casteleiro C . Conjugated linoleic acid-induced toxic hepatitis: first case report. Dig Dis Sci. 2008; 54(5):1141-3. DOI: 10.1007/s10620-008-0461-1. View

18.

Kitano M, Watanabe D, Oda S, Kubo H, Kishida H, Fujii K . Subchronic oral toxicity of ubiquinol in rats and dogs. Int J Toxicol. 2008; 27(2):189-215. DOI: 10.1080/10915810801978060. View