Wound Repair: Toward Understanding and Integration of Single-cell and Multicellular Wound Responses

Overview

Journal Annu Rev Cell Dev Biol

Publisher Annual Reviews

Specialty Cell Biology

Date 2011 Jul 5

PMID 21721944

Citations 150

Authors

Kevin J Sonnemann

William M Bement

Affiliations

Soon will be listed here.

Abstract

The importance of wound healing to medicine and biology has long been evident, and consequently, wound healing has been the subject of intense investigation for many years. However, several relatively recent developments have added new impetus to wound repair research: the increasing application of model systems; the growing recognition that single cells have a robust, complex, and medically relevant wound healing response; and the emerging recognition that different modes of wound repair bear an uncanny resemblance to other basic biological processes such as morphogenesis and cytokinesis. In this review, each of these developments is described, and their significance for wound healing research is considered. In addition, overlapping mechanisms of single-cell and multicellular wound healing are highlighted, and it is argued that they are more similar than is often recognized. Based on this and other information, a simple model to explain the evolutionary relationships of cytokinesis, single-cell wound repair, multicellular wound repair, and developmental morphogenesis is proposed. Finally, a series of important, but as yet unanswered, questions is posed.

Citing Articles

Enhanced myofibroblast differentiation of eMSCs in intrauterine adhesions.

Song J, Li M, Tao Y, Li Y, Mai C, Zhang J Stem Cell Res Ther. 2025; 16(1):35.

PMID: 39901307 PMC: 11792338. DOI: 10.1186/s13287-025-04183-y.

Role of the GalNAc-galectin pathway in the healing of premature rupture of membranes.

Chen J, Liu L, Peng X, Wang Y, Xiang X, Chen Y Mol Med. 2024; 30(1):138.

PMID: 39232672 PMC: 11375961. DOI: 10.1186/s10020-024-00908-6.

Damage-induced basal epithelial cell migration modulates the spatial organization of redox signaling and sensory neuron regeneration.

Fister A, Horn A, Lasarev M, Huttenlocher A Elife. 2024; 13.

PMID: 39207919 PMC: 11361710. DOI: 10.7554/eLife.94995.

The Therapeutic Potential of Human Umbilical Cord Mesenchymal Stromal Cells Derived Exosomes for Wound Healing: Harnessing Exosomes as a Cell-free Therapy.

Dehghani L, Owliaee I, Sadeghian F, Shojaeian A J Stem Cells Regen Med. 2024; 20(1):14-23.

PMID: 39044811 PMC: 11262847. DOI: 10.46582/jsrm.2003003.

Calcium influx rapidly establishes distinct spatial recruitments of Annexins to cell wounds.

Nakamura M, Parkhurst S Genetics. 2024; 227(4).

PMID: 38874345 PMC: 11304956. DOI: 10.1093/genetics/iyae101.

References

Danilchik M, Brown E . Membrane dynamics of cleavage furrow closure in Xenopus laevis. Dev Dyn. 2008; 237(3):565-79. DOI: 10.1002/dvdy.21442. View

Delley P, Hall M . Cell wall stress depolarizes cell growth via hyperactivation of RHO1. J Cell Biol. 1999; 147(1):163-74. PMC: 2164985. DOI: 10.1083/jcb.147.1.163. View

Rosenblatt J, Raff M, Cramer L . An epithelial cell destined for apoptosis signals its neighbors to extrude it by an actin- and myosin-dependent mechanism. Curr Biol. 2001; 11(23):1847-57. DOI: 10.1016/s0960-9822(01)00587-5. View

Joshi S, von Dassow M, Davidson L . Experimental control of excitable embryonic tissues: three stimuli induce rapid epithelial contraction. Exp Cell Res. 2009; 316(1):103-14. PMC: 2789981. DOI: 10.1016/j.yexcr.2009.08.005. View

Wu J, Ye Y, Wang N, Pollard T, Pringle J . Cooperation between the septins and the actomyosin ring and role of a cell-integrity pathway during cell division in fission yeast. Genetics. 2010; 186(3):897-915. PMC: 2975288. DOI: 10.1534/genetics.110.119842. View

Godell C, Smyers M, Eddleman C, Ballinger M, Fishman H, Bittner G . Calpain activity promotes the sealing of severed giant axons. Proc Natl Acad Sci U S A. 1997; 94(9):4751-6. PMC: 20796. DOI: 10.1073/pnas.94.9.4751. View

Huh C, Factor V, Sanchez A, Uchida K, Conner E, Thorgeirsson S . Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair. Proc Natl Acad Sci U S A. 2004; 101(13):4477-82. PMC: 384772. DOI: 10.1073/pnas.0306068101. View

Togo T, Krasieva T, Steinhardt R . A decrease in membrane tension precedes successful cell-membrane repair. Mol Biol Cell. 2000; 11(12):4339-46. PMC: 15076. DOI: 10.1091/mbc.11.12.4339. View

Pearson J, Juarez M, Kim M, Drivenes O, McGinnis W . Multiple transcription factor codes activate epidermal wound-response genes in Drosophila. Proc Natl Acad Sci U S A. 2009; 106(7):2224-9. PMC: 2630199. DOI: 10.1073/pnas.0810219106. View

10.

Janis J, Kwon R, Lalonde D . A practical guide to wound healing. Plast Reconstr Surg. 2010; 125(6):230e-244e. DOI: 10.1097/PRS.0b013e3181d9a0d1. View

11.

Heasman S, Ridley A . Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat Rev Mol Cell Biol. 2008; 9(9):690-701. DOI: 10.1038/nrm2476. View

12.

Weber K, Klickstein L, Weber P, Weber C . Chemokine-induced monocyte transmigration requires cdc42-mediated cytoskeletal changes. Eur J Immunol. 1998; 28(7):2245-51. DOI: 10.1002/(SICI)1521-4141(199807)28:07<2245::AID-IMMU2245>3.0.CO;2-V. View

13.

Mace K, Pearson J, McGinnis W . An epidermal barrier wound repair pathway in Drosophila is mediated by grainy head. Science. 2005; 308(5720):381-5. DOI: 10.1126/science.1107573. View

14.

Klinge L, Laval S, Keers S, Haldane F, Straub V, Barresi R . From T-tubule to sarcolemma: damage-induced dysferlin translocation in early myogenesis. FASEB J. 2007; 21(8):1768-76. DOI: 10.1096/fj.06-7659com. View

15.

Stramer B, Wood W, Galko M, Redd M, Jacinto A, Parkhurst S . Live imaging of wound inflammation in Drosophila embryos reveals key roles for small GTPases during in vivo cell migration. J Cell Biol. 2005; 168(4):567-73. PMC: 2171743. DOI: 10.1083/jcb.200405120. View

16.

Lennon N, Kho A, Bacskai B, Perlmutter S, Hyman B, Brown Jr R . Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing. J Biol Chem. 2003; 278(50):50466-73. DOI: 10.1074/jbc.M307247200. View

17.

Duffield J . Epithelial to mesenchymal transition in injury of solid organs: fact or artifact?. Gastroenterology. 2010; 139(4):1081-3, 1083.e1-5. DOI: 10.1053/j.gastro.2010.08.017. View

18.

Niethammer P, Grabher C, Look A, Mitchison T . A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish. Nature. 2009; 459(7249):996-9. PMC: 2803098. DOI: 10.1038/nature08119. View

19.

Young P, Richman A, KETCHUM A, Kiehart D . Morphogenesis in Drosophila requires nonmuscle myosin heavy chain function. Genes Dev. 1993; 7(1):29-41. DOI: 10.1101/gad.7.1.29. View

20.

Bullen T, Forrest S, Campbell F, Dodson A, Hershman M, Pritchard D . Characterization of epithelial cell shedding from human small intestine. Lab Invest. 2006; 86(10):1052-63. DOI: 10.1038/labinvest.3700464. View