Botanical Flavonoids on Coronary Heart Disease

Overview

Journal Am J Chin Med

Specialty Rehabilitation Medicine

Date 2011 Jul 2

PMID 21721147

Citations 26

Authors

Chong-Zhi Wang

Sangeeta R Mehendale

Tyler Calway

Chun-Su Yuan

Affiliations

Soon will be listed here.

Abstract

Ischemic heart disease (IHD) is one of the leading causes of death in Western countries. Prevention rather than treatment of heart disease can significantly improve patients' quality of life and reduce health care costs. Flavonoids are widely distributed in vegetables, fruits and herbal medicines. Regularly consuming botanicals, especially those containing flavonoids, has been associated with a reduction in cardiovascualar disease; thus, it is important to investigate how flavonoids improve cardiac resistance to heart disease and their related mechanisms of action. It has been shown that cardiomyocyte injury and death can result from ischemia-reperfusion, which is pathognomonic of ischemic heart disease. Massive reactive oxygen species (ROS) release at the onset of reperfusion produces cell injury and death. "Programming" the heart to either generate less ROS or to increase strategic ROS removal could reduce reperfusion response. Additionally, profuse nitric oxide (NO) release at reperfusion could be protective in "preconditioning" models. Botanical flavonoids induce preconditioning of the heart, thereby protecting against ischemia-reperfusion injury. In this article, we will discuss two herbs containing potent flavonoids, Scutellaria baicalensis and grape seed proanthocyanidin, which can potentially offer cardiac protection against ischemic heart disease.

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References

Roychowdhury S, Wolf G, Keilhoff G, Bagchi D, Horn T . Protection of primary glial cells by grape seed proanthocyanidin extract against nitrosative/oxidative stress. Nitric Oxide. 2001; 5(2):137-49. DOI: 10.1006/niox.2001.0335. View

Stohs S . The role of free radicals in toxicity and disease. J Basic Clin Physiol Pharmacol. 1995; 6(3-4):205-28. DOI: 10.1515/jbcpp.1995.6.3-4.205. View

Wang W, Zu Y, Fu Y, Reichling J, Suschke U, Nokemper S . In vitro antioxidant, antimicrobial and anti-herpes simplex virus type 1 activity of Phellodendron amurense Rupr. from China. Am J Chin Med. 2009; 37(1):195-203. DOI: 10.1142/S0192415X09006655. View

Stein J, Keevil J, Wiebe D, Aeschlimann S, Folts J . Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation. 1999; 100(10):1050-5. DOI: 10.1161/01.cir.100.10.1050. View

Shao Z, Vanden Hoek T, Qin Y, Becker L, Schumacker P, Li C . Baicalein attenuates oxidant stress in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2002; 282(3):H999-H1006. DOI: 10.1152/ajpheart.00163.2001. View

Shao Z, Wojcik K, Dossumbekova A, Hsu C, Mehendale S, Li C . Grape seed proanthocyanidins protect cardiomyocytes from ischemia and reperfusion injury via Akt-NOS signaling. J Cell Biochem. 2009; 107(4):697-705. DOI: 10.1002/jcb.22170. View

Zweier J, Flaherty J, WEISFELDT M . Direct measurement of free radical generation following reperfusion of ischemic myocardium. Proc Natl Acad Sci U S A. 1987; 84(5):1404-7. PMC: 304438. DOI: 10.1073/pnas.84.5.1404. View

Yamashita S, Sakane T, Harada M, Sugiura N, Koda H, Kiso Y . Absorption and metabolism of antioxidative polyphenolic compounds in red wine. Ann N Y Acad Sci. 2002; 957:325-8. DOI: 10.1111/j.1749-6632.2002.tb02934.x. View

Gonzalez-Paramas A, Esteban-Ruano S, Santos-Buelga C, de Pascual-Teresa S, Rivas-Gonzalo J . Flavanol content and antioxidant activity in winery byproducts. J Agric Food Chem. 2004; 52(2):234-8. DOI: 10.1021/jf0348727. View

10.

Gao D, Sakurai K, Chen J, Ogiso T . Protection by baicalein against ascorbic acid-induced lipid peroxidation of rat liver microsomes. Res Commun Mol Pathol Pharmacol. 1995; 90(1):103-14. View

11.

Das D, Sato M, Ray P, Maulik G, Engelman R, Bertelli A . Cardioprotection of red wine: role of polyphenolic antioxidants. Drugs Exp Clin Res. 1999; 25(2-3):115-20. View

12.

Fitzpatrick D, Bing B, Maggi D, Fleming R, OMalley R . Vasodilating procyanidins derived from grape seeds. Ann N Y Acad Sci. 2002; 957:78-89. DOI: 10.1111/j.1749-6632.2002.tb02907.x. View

13.

Lai M, Hsiu S, Tsai S, Hou Y, Chao P . Comparison of metabolic pharmacokinetics of baicalin and baicalein in rats. J Pharm Pharmacol. 2003; 55(2):205-9. DOI: 10.1211/002235702522. View

14.

Gasiorowski K, Lamer-Zarawska E, Leszek J, Parvathaneni K, Yendluri B, Blach-Olszewska Z . Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration?. CNS Neurol Disord Drug Targets. 2011; 10(2):184-91. DOI: 10.2174/187152711794480384. View

15.

Yune T, Lee J, Cui C, Kim H, Oh T . Neuroprotective effect of Scutellaria baicalensis on spinal cord injury in rats. J Neurochem. 2009; 110(4):1276-87. DOI: 10.1111/j.1471-4159.2009.06214.x. View

16.

Baxter G, Ferdinandy P . Delayed preconditioning of myocardium: current perspectives. Basic Res Cardiol. 2001; 96(4):329-44. DOI: 10.1007/s003950170041. View

17.

Keli S, Hertog M, Feskens E, Kromhout D . Dietary flavonoids, antioxidant vitamins, and incidence of stroke: the Zutphen study. Arch Intern Med. 1996; 156(6):637-42. View

18.

Hosny M, Rosazza J . Novel oxidations of (+)-catechin by horseradish peroxidase and laccase. J Agric Food Chem. 2002; 50(20):5539-45. DOI: 10.1021/jf020503j. View

19.

Konishi Y, Kobayashi S, Shimizu M . Tea polyphenols inhibit the transport of dietary phenolic acids mediated by the monocarboxylic acid transporter (MCT) in intestinal Caco-2 cell monolayers. J Agric Food Chem. 2003; 51(25):7296-302. DOI: 10.1021/jf034894t. View

20.

Schulz R, Kelm M, Heusch G . Nitric oxide in myocardial ischemia/reperfusion injury. Cardiovasc Res. 2004; 61(3):402-13. DOI: 10.1016/j.cardiores.2003.09.019. View