Antimicrobial Prophylaxis in Adults

Overview

Journal Mayo Clin Proc

Specialty General Medicine

Date 2011 Jul 2

PMID 21719623

Citations 52

Authors

Mark J Enzler

Elie Berbari

Douglas R Osmon

Affiliations

Soon will be listed here.

Abstract

Antimicrobial prophylaxis is commonly used by clinicians for the prevention of numerous infectious diseases, including herpes simplex infection, rheumatic fever, recurrent cellulitis, meningococcal disease, recurrent uncomplicated urinary tract infections in women, spontaneous bacterial peritonitis in patients with cirrhosis, influenza, infective endocarditis, pertussis, and acute necrotizing pancreatitis, as well as infections associated with open fractures, recent prosthetic joint placement, and bite wounds. Perioperative antimicrobial prophylaxis is recommended for various surgical procedures to prevent surgical site infections. Optimal antimicrobial agents for prophylaxis should be bactericidal, nontoxic, inexpensive, and active against the typical pathogens that can cause surgical site infection postoperatively. To maximize its effectiveness, intravenous perioperative prophylaxis should be administered within 30 to 60 minutes before the surgical incision. Antimicrobial prophylaxis should be of short duration to decrease toxicity and antimicrobial resistance and to reduce cost.

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References

Singh N, Gayowski T, Yu V, Wagener M . Trimethoprim-sulfamethoxazole for the prevention of spontaneous bacterial peritonitis in cirrhosis: a randomized trial. Ann Intern Med. 1995; 122(8):595-8. DOI: 10.7326/0003-4819-122-8-199504150-00007. View

Ansdell V, Ericsson C . Prevention and empiric treatment of traveler's diarrhea. Med Clin North Am. 1999; 83(4):945-73, vi. View

Fiore A, Shay D, Broder K, Iskander J, Uyeki T, Mootrey G . Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2008. MMWR Recomm Rep. 2008; 57(RR-7):1-60. View

Baddour L, Epstein A, Erickson C, Knight B, Levison M, Lockhart P . Update on cardiovascular implantable electronic device infections and their management: a scientific statement from the American Heart Association. Circulation. 2010; 121(3):458-77. DOI: 10.1161/CIRCULATIONAHA.109.192665. View

Melekos M, Asbach H, Gerharz E, Zarakovitis I, Weingaertner K, Naber K . Post-intercourse versus daily ciprofloxacin prophylaxis for recurrent urinary tract infections in premenopausal women. J Urol. 1997; 157(3):935-9. View

Little J . Patients with prosthetic joints: are they at risk when receiving invasive dental procedures?. Spec Care Dentist. 1998; 17(5):153-60. DOI: 10.1111/j.1754-4505.1997.tb00888.x. View

Hill D, Ericsson C, Pearson R, Keystone J, Freedman D, Kozarsky P . The practice of travel medicine: guidelines by the Infectious Diseases Society of America. Clin Infect Dis. 2006; 43(12):1499-539. DOI: 10.1086/508782. View

Jorup-Ronstrom C, Britton S . Recurrent erysipelas: predisposing factors and costs of prophylaxis. Infection. 1987; 15(2):105-6. DOI: 10.1007/BF01650206. View

Gupta K, Hooton T, Roberts P, Stamm W . Patient-initiated treatment of uncomplicated recurrent urinary tract infections in young women. Ann Intern Med. 2001; 135(1):9-16. DOI: 10.7326/0003-4819-135-1-200107030-00004. View

10.

Villatoro E, Mulla M, Larvin M . Antibiotic therapy for prophylaxis against infection of pancreatic necrosis in acute pancreatitis. Cochrane Database Syst Rev. 2010; (5):CD002941. PMC: 7138080. DOI: 10.1002/14651858.CD002941.pub3. View

11.

. American Academy of Pediatrics. Committee on Infectious Diseases. Policy statement: recommendations for the prevention of pneumococcal infections, including the use of pneumococcal conjugate vaccine (Prevnar), pneumococcal polysaccharide vaccine,.... Pediatrics. 2000; 106(2 Pt 1):362-6. DOI: 10.1542/peds.106.2.362. View

12.

Liesegang T . Perioperative antibiotic prophylaxis in cataract surgery. Cornea. 1999; 18(4):383-402. DOI: 10.1097/00003226-199907000-00001. View

13.

Oliver G, Lowry A, Vernava A, Hicks T, Burnstein M, Denstman F . Practice parameters for antibiotic prophylaxis--supporting documentation. The Standards Task Force. The American Society of Colon and Rectal Surgeons. Dis Colon Rectum. 2000; 43(9):1194-200. DOI: 10.1007/BF02237420. View

14.

Berbari E, Osmon D, Carr A, Hanssen A, Baddour L, Greene D . Dental procedures as risk factors for prosthetic hip or knee infection: a hospital-based prospective case-control study. Clin Infect Dis. 2009; 50(1):8-16. DOI: 10.1086/648676. View

15.

Cohen M, Sahar T, Benenson S, Elinav E, Brezis M, Soares-Weiser K . Antibiotic prophylaxis for spontaneous bacterial peritonitis in cirrhotic patients with ascites, without gastro-intestinal bleeding. Cochrane Database Syst Rev. 2009; (2):CD004791. DOI: 10.1002/14651858.CD004791.pub2. View

16.

Zimmerli W, Trampuz A, Ochsner P . Prosthetic-joint infections. N Engl J Med. 2004; 351(16):1645-54. DOI: 10.1056/NEJMra040181. View

17.

Lockhart P, Loven B, Brennan M, Fox P . The evidence base for the efficacy of antibiotic prophylaxis in dental practice. J Am Dent Assoc. 2007; 138(4):458-74. DOI: 10.14219/jada.archive.2007.0198. View

18.

Bratzler D, Houck P . Antimicrobial prophylaxis for surgery: an advisory statement from the National Surgical Infection Prevention Project. Clin Infect Dis. 2004; 38(12):1706-15. DOI: 10.1086/421095. View

19.

Forsmark C, Baillie J . AGA Institute technical review on acute pancreatitis. Gastroenterology. 2007; 132(5):2022-44. DOI: 10.1053/j.gastro.2007.03.065. View

20.

. Antibiotic prophylaxis for urological patients with total joint replacements. J Urol. 2003; 169(5):1796-7. DOI: 10.1097/01.ju.0000062420.06536.57. View