Benzeneselenenyl Triflate As an Activator of Thioglycosides for Glycosylation Reactions

Overview

Journal Carbohydr Res

Publisher Elsevier

Specialties Biochemistry
Endocrinology

Date 1990 Jul 15

PMID 2171765

Citations 5

Authors

Y Ito

T Ogawa

M Numata

M Sugimoto

Affiliations

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Abstract

A new method for the activation of thioglycosides was developed by use of benzeneselenenyl triflate (PhSeOTf), which, upon reaction with either a primary or secondary sugar HO-group, afforded O-glycosides under extremely mild reaction conditions. The reaction was applicable to various l-thiohexosides 2-6 as well as to a 2-thioglycoside 20 derived from N-acetylneuraminic acid (NeuAc).

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