[Use of Nanoparticles in Ophthalomology]

Overview

Journal Ophthalmologe

Specialty Ophthalmology

Date 2011 Jul 1

PMID 21717225

Authors

I Hahn

P Heiduschka

E Endl

N Eter

Affiliations

Soon will be listed here.

Abstract

Nanotechnology, the manufacture and use of structures and implements of around a few 100 nm in size, is becoming a key technology of the twenty-first century. An important element for the manufacture of nanoparticles is gold. Gold nanoparticles can be custom made and chemically modified in their size and form. Initial investigations have shown that they are physiologically non-hazardous. A potential application is in neovascular age-related macular degeneration. Gold nanoparticles of suitable dimensions introduced into newly forming blood vessels can be targeted and heated which selectively destroys these blood vessels. This principle has already been demonstrated in cultivated endothelial cells.

References

Zarbin M, Montemagno C, Leary J, Ritch R . Nanotechnology in ophthalmology. Can J Ophthalmol. 2010; 45(5):457-76. DOI: 10.3129/i10-090. View

Bakri S, Pulido J, Mukherjee P, Marler R, Mukhopadhyay D . Absence of histologic retinal toxicity of intravitreal nanogold in a rabbit model. Retina. 2008; 28(1):147-9. DOI: 10.1097/IAE.0b013e3180dc9360. View

van Landeghem F, Maier-Hauff K, Jordan A, Hoffmann K, Gneveckow U, Scholz R . Post-mortem studies in glioblastoma patients treated with thermotherapy using magnetic nanoparticles. Biomaterials. 2008; 30(1):52-7. DOI: 10.1016/j.biomaterials.2008.09.044. View

Jiang C, Moore M, Zhang X, Klassen H, Langer R, Young M . Intravitreal injections of GDNF-loaded biodegradable microspheres are neuroprotective in a rat model of glaucoma. Mol Vis. 2007; 13:1783-92. View

Wang J, Sui M, Fan W . Nanoparticles for tumor targeted therapies and their pharmacokinetics. Curr Drug Metab. 2010; 11(2):129-41. DOI: 10.2174/138920010791110827. View

Drexler K . Molecular engineering: An approach to the development of general capabilities for molecular manipulation. Proc Natl Acad Sci U S A. 1981; 78(9):5275-8. PMC: 348724. DOI: 10.1073/pnas.78.9.5275. View

Caruthers S, Wickline S, Lanza G . Nanotechnological applications in medicine. Curr Opin Biotechnol. 2007; 18(1):26-30. DOI: 10.1016/j.copbio.2007.01.006. View

Chu T, He Q, Potter D . Biodegradable calcium phosphate nanoparticles as a new vehicle for delivery of a potential ocular hypotensive agent. J Ocul Pharmacol Ther. 2003; 18(6):507-14. DOI: 10.1089/108076802321021054. View

Nguyen P, Meyyappan M, Yiu S . Applications of nanobiotechnology in ophthalmology--Part I. Ophthalmic Res. 2010; 44(1):1-16. DOI: 10.1159/000279436. View

10.

Maier-Hauff K, Ulrich F, Nestler D, Niehoff H, Wust P, Thiesen B . Efficacy and safety of intratumoral thermotherapy using magnetic iron-oxide nanoparticles combined with external beam radiotherapy on patients with recurrent glioblastoma multiforme. J Neurooncol. 2010; 103(2):317-24. PMC: 3097345. DOI: 10.1007/s11060-010-0389-0. View

11.

Cai X, Conley S, Naash M . Nanoparticle applications in ocular gene therapy. Vision Res. 2007; 48(3):319-24. PMC: 2423345. DOI: 10.1016/j.visres.2007.07.012. View

12.

Cobley C, Au L, Chen J, Xia Y . Targeting gold nanocages to cancer cells for photothermal destruction and drug delivery. Expert Opin Drug Deliv. 2010; 7(5):577-87. PMC: 2858262. DOI: 10.1517/17425240903571614. View

13.

Boisselier E, Astruc D . Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity. Chem Soc Rev. 2009; 38(6):1759-82. DOI: 10.1039/b806051g. View

14.

Bejjani R, Benezra D, Cohen H, Rieger J, Andrieu C, Jeanny J . Nanoparticles for gene delivery to retinal pigment epithelial cells. Mol Vis. 2005; 11:124-32. View

15.

Chader G, Weiland J, Humayun M . Artificial vision: needs, functioning, and testing of a retinal electronic prosthesis. Prog Brain Res. 2009; 175:317-32. DOI: 10.1016/S0079-6123(09)17522-2. View

16.

Marano R, Toth I, Wimmer N, Brankov M, Rakoczy P . Dendrimer delivery of an anti-VEGF oligonucleotide into the eye: a long-term study into inhibition of laser-induced CNV, distribution, uptake and toxicity. Gene Ther. 2005; 12(21):1544-50. DOI: 10.1038/sj.gt.3302579. View

17.

Huang X, Jain P, El-Sayed I, El-Sayed M . Gold nanoparticles: interesting optical properties and recent applications in cancer diagnostics and therapy. Nanomedicine (Lond). 2007; 2(5):681-93. DOI: 10.2217/17435889.2.5.681. View

18.

Jani P, Singh N, Jenkins C, Raghava S, Mo Y, Amin S . Nanoparticles sustain expression of Flt intraceptors in the cornea and inhibit injury-induced corneal angiogenesis. Invest Ophthalmol Vis Sci. 2007; 48(5):2030-6. DOI: 10.1167/iovs.06-0853. View

19.

Yang D, Cui D . Advances and prospects of gold nanorods. Chem Asian J. 2008; 3(12):2010-22. DOI: 10.1002/asia.200800195. View

20.

Mukherjee P, Bhattacharya R, Wang P, Wang L, Basu S, Nagy J . Antiangiogenic properties of gold nanoparticles. Clin Cancer Res. 2005; 11(9):3530-4. DOI: 10.1158/1078-0432.CCR-04-2482. View