Role of Common-gamma Chain Cytokines in NK Cell Development and Function: Perspectives for Immunotherapy

Overview

Journal J Biomed Biotechnol

Specialty Biology

Date 2011 Jul 1

PMID 21716670

Citations 56

Authors

Raffaella Meazza

Bruno Azzarone

Anna Maria Orengo

Silvano Ferrini

Affiliations

Soon will be listed here.

Abstract

NK cells are components of the innate immunity system and play an important role as a first-line defense mechanism against viral infections and in tumor immune surveillance. Their development and their functional activities are controlled by several factors among which cytokines sharing the usage of the common cytokine-receptor gamma chain play a pivotal role. In particular, IL-2, IL-7, IL-15, and IL-21 are the members of this family predominantly involved in NK cell biology. In this paper, we will address their role in NK cell ontogeny, regulation of functional activities, development of specialized cell subsets, and acquisition of memory-like functions. Finally, the potential application of these cytokines as recombinant molecules to NK cell-based immunotherapy approaches will be discussed.

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