Evolution of Antimicrobial Resistance of Acinetobacter Baumannii in a University Hospital

Overview

Journal Lett Appl Microbiol

Publisher Oxford University Press

Specialty Microbiology

Date 2011 Jun 29

PMID 21707678

Citations 4

Authors

G F Viana

S M dos Santos Saalfeld

L B Garcia

C L Cardoso

M Pelisson

M C B Tognim

Affiliations

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Abstract

Aims: To investigate the susceptibility pattern and the molecular epidemiology of Acinetobacter baumannii isolates in two periods (1994-1996 and 2004-2007) in Londrina University Hospital.

Methods And Results: Antimicrobial susceptibility of 150 A. baumannii isolates was assessed by disc diffusion and agar dilution methods. Genetic similarity amongst the isolates was evaluated by ERIC-PCR. Resistance of A. baumannii to carbapenems increased from 2% (1994-1996) to 73% (2004-2007). Thirty-eight clones were detected.

Conclusions: The results of the study suggest that the high prevalence of carbapenem resistance amongst Acinetobacter baumannii organisms in this institution is not caused by the spread of a predominant clone.

Significance And Impact Of The Study: This work reinforces the importance monitoring antimicrobial susceptibility rates.

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Emergence and spread of carbapenem-resistant Acinetobacter baumannii international clones II and III in Lima, Peru.

Levy-Blitchtein S, Roca I, Plasencia-Rebata S, Vicente-Taboada W, Velasquez-Pomar J, Munoz L Emerg Microbes Infect. 2018; 7(1):119.

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Increasing resistance rate to carbapenem among blood culture isolates of Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa in a university-affiliated hospital in China, 2004-2011.

Zhang X, Gu B, Mei Y, Wen Y, Xia W J Antibiot (Tokyo). 2014; 68(2):115-20.

PMID: 25182483 DOI: 10.1038/ja.2014.119.

Nosocomial Acinetobacter baumannii Infections and Changing Antibiotic Resistance.

Hakyemez I, Kucukbayrak A, Tas T, Burcu Yikilgan A, Akkaya A, Yasayacak A Pak J Med Sci. 2013; 29(5):1245-8.

PMID: 24353729 PMC: 3858953. DOI: 10.12669/pjms.295.3885.