Viral Proteomics: the Emerging Cutting-edge of Virus Research

Overview

Journal Sci China Life Sci

Specialties Biology
Science

Date 2011 Jun 28

PMID 21706410

Citations 8

Authors

Shengtao Zhou

Rui Liu

Xia Zhao

Canhua Huang

Yuquan Wei

Affiliations

Soon will be listed here.

Abstract

Viruses replicate and proliferate in host cells while continuously adjusting to and modulating the host environment. They encode a wide spectrum of multifunctional proteins, which interplay with and modify proteins in host cells. Viral genomes were chronologically the first to be sequenced. However, the corresponding viral proteomes, the alterations of host proteomes upon viral infection, and the dynamic nature of proteins, such as post-translational modifications, enzymatic cleavage, and activation or destruction by proteolysis, remain largely unknown. Emerging high-throughput techniques, in particular quantitative or semi-quantitative mass spectrometry-based proteomics analysis of viral and cellular proteomes, have been applied to define viruses and their interactions with their hosts. Here, we review the major areas of viral proteomics, including virion proteomics, structural proteomics, viral protein interactomics, and changes to the host cell proteome upon viral infection.

Citing Articles

Application of Proteomics Technology Based on LC-MS Combined with Western Blotting and Co-IP in Antiviral Innate Immunity.

Liang W, Zhu Z, Zheng C Methods Mol Biol. 2024; 2854:93-106.

PMID: 39192122 DOI: 10.1007/978-1-0716-4108-8_11.

Mass Spectrometry-Based Characterization of the Virion Proteome, Phosphoproteome, and Associated Kinase Activity of Human Cytomegalovirus.

Coute Y, Kraut A, Zimmermann C, Buscher N, Hesse A, Bruley C Microorganisms. 2020; 8(6).

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Plasma L-Carnitine and L-Lysine Concentrations in HIV-Infected Patients.

Butorov E Open Biochem J. 2018; 11:119-131.

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Human borna disease virus infection impacts host proteome and histone lysine acetylation in human oligodendroglia cells.

Liu X, Zhao L, Yang Y, Bode L, Huang H, Liu C Virology. 2014; 464-465:196-205.

PMID: 25086498 PMC: 7112117. DOI: 10.1016/j.virol.2014.06.040.

Proteomics reveal energy metabolism and mitogen-activated protein kinase signal transduction perturbation in human Borna disease virus Hu-H1-infected oligodendroglial cells.

Liu X, Yang Y, Zhao M, Bode L, Pan J, Lv L Neuroscience. 2014; 268:284-96.

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