Long-term Lead Elimination from Plasma and Whole Blood After Poisoning

Overview

Journal Int Arch Occup Environ Health

Specialty Environmental Health

Date 2011 Jun 25

PMID 21701834

Citations 9

Authors

Gerda Rentschler

K Broberg

T Lundh

S Skerfving

Affiliations

Soon will be listed here.

Abstract

Objective: Blood lead (B-Pb), one of the most used toxicological biomarker all kind, has serious limitations. Thus, the objective is to evaluate whether plasma lead (P-Pb) is more adequate.

Methods: A long-term follow-up study of five cases of lead poisoning. P-Pb was analysed by inductively coupled plasma mass spectrometry. Kinetics after end of exposure was modelled.

Results: P-Pb at severe poisoning was about 20 μg/L; haematological effects at about 5 μg/L. Biological half-time of P-Pb was about 1 month; B-Pb decay was much slower.

Conclusion: P-Pb is a valuable biomarker of exposure to and risk, particularly at high exposure.

Citing Articles

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