Hypothermia is Correlated with Seizure Absence in Perinatal Stroke

Overview

Journal J Child Neurol

Specialties Neurology
Pediatrics

Date 2011 Jun 25

PMID 21700899

Citations 25

Authors

Mary J Harbert

Emily W Y Tam

Hannah C Glass

Sonia L Bonifacio

Laurel A Haeusslein

A James Barkovich

Rita J Jeremy

Elizabeth E Rogers

David V Glidden

Donna M Ferriero

Affiliations

Soon will be listed here.

Abstract

Within a single-center prospective cohort study of neonatal encephalopathy involving 315 subjects, 15 neonates were found to have a focal stroke on magnetic resonance imaging. These 15 patients were matched on the basis of gender and degree of encephalopathy to 30 neonates without stroke from the same cohort. On Bayley Scales of Infant Development, the stroke group had Mental Development Index scores that were 1.7 standard deviations lower compared with controls (P = .007). This association was no longer seen after adjustment for the presence of neonatal seizures (P = .11). Of the 15 patients with stroke, 5 had been treated with hypothermia. None of these 5 had seizures in the neonatal period, compared with 7 of the untreated 10. This is the first human study to demonstrate a potential treatment effect of therapeutic hypothermia on perinatal stroke. It was also shown that seizures are associated with worse cognitive outcomes for stroke that presents with encephalopathy.

Citing Articles

Perinatal arterial ischemic stroke diagnosed in infants receiving therapeutic hypothermia for hypoxic-ischemic encephalopathy.

Gonzalez F, Monsell S, Cornet M, Glass H, Wisnowski J, Mathur A Pediatr Res. 2024; .

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MRI predictors of long-term outcomes of neonatal hypoxic ischaemic encephalopathy: a primer for radiologists.

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Magnetic Resonance Imaging in (Near-)Term Infants with Hypoxic-Ischemic Encephalopathy.

Parmentier C, de Vries L, Groenendaal F Diagnostics (Basel). 2022; 12(3).

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Transcranial photoacoustic characterization of neurovascular physiology during early-stage photothrombotic stroke in neonatal piglets.

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Preclinical assessment of thrombin-preconditioned human Wharton's jelly-derived mesenchymal stem cells for neonatal hypoxic-ischaemic brain injury.

Noh J, Jeong J, Park S, Jung K, Lee B, Kim W J Cell Mol Med. 2021; 25(22):10430-10440.

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