SH2-containing Inositol 5'-phosphatase Inhibits Transformation of Abelson Murine Leukemia Virus

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2011 Jun 24

PMID 21697469

Authors

Shawn P Fessler

Naomi Rosenberg

Linda B Baughn

Affiliations

Soon will be listed here.

Abstract

v-Abl protein tyrosine kinase encoded by Abelson murine leukemia virus (Ab-MLV) transforms pre-B cells. Transformation requires the phosphatidylinositol 3-kinase (PI3K) pathway. This pathway is antagonized by SH2-containing inositol 5'-phosphatase (SHIP), raising the possibility that v-Abl modulates PI3K signaling through SHIP. Consistent with this, we show that v-Abl expression reduces levels of full-length p145 SHIP in a v-Abl kinase activity-dependent fashion. This event requires signals from the Abl SH2 domain but not the carboxyl terminus. Forced expression of full-length SHIP significantly reduces Ab-MLV pre-B-cell transformation. Therefore, reduction of SHIP protein by v-Abl is a critical component in Ab-MLV transformation.

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