Characteristics and Comorbidity of ADHD Sib Pairs in the Central Valley of Costa Rica

Overview

Journal Compr Psychiatry

Specialty Psychiatry

Date 2011 Jun 24

PMID 21696714

Citations 3

Authors

Jovita Schuler

Nicholas T Weiss

Denise A Chavira

James J McGough

Monica Berrocal

Brooke Sheppard

Evelyn Vaglio

Eduardo Fournier

Luis Diego Herrera

Carol A Mathews

Affiliations

Soon will be listed here.

Abstract

Background: While genetic epidemiological studies demonstrate a substantial degree of genetic predisposition for attention-deficit/hyperactivity disorder (ADHD), they also suggest that the genetics are complex and may differ between populations or ethnic groups.

Objective: This study describes the phenomenology of siblings with ADHD from the genetically isolated population of the Central Valley of Costa Rica.

Methods: Rates of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV)-defined ADHD subtypes and comorbid conditions were calculated in a sample of 157 ADHD-affected children (probands and siblings) recruited for genetic studies using standardized approaches. Sib-sib comparisons and logistic regressions were conducted to identify significant patterns of concordance.

Results: Combined-type ADHD (69.5%) was the most common subtype among probands, followed by the inattentive (27.4%), and hyperactive-impulsive (3.2%) subtypes. Anxiety disorders were prevalent (55.9%), as were disruptive behavior disorders (30.9%) and Tourette disorder (17.0%). Probands and siblings showed high sib-sib concordance for anxiety disorders.

Conclusions: ADHD in Costa Rica is similar in clinical and demographic characteristics to ADHD seen in other parts of the world, although the rates of co-occurring psychiatric disorders differ somewhat from those previously reported in Latin American samples. Comorbid anxiety is prevalent, with high rates of sib-sib concordance, and may represent a distinct, homogeneous subgroup suitable for genetic studies.

Citing Articles

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Neuropsychological and dimensional behavioral trait profiles in Costa Rican ADHD sib pairs: Potential intermediate phenotypes for genetic studies.

Peskin V, Ordonez A, Mackin R, Delucchi K, Monge S, McGough J Am J Med Genet B Neuropsychiatr Genet. 2015; 168B(4):247-57.

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