Direct Intra-accumbal Infusion of a Beta-adrenergic Receptor Antagonist Abolishes WIN 55,212-2-induced Aversion

Overview

Journal Neurosci Lett

Specialty Neurology

Date 2011 Jun 23

PMID 21693171

Citations 6

Authors

Ana Franky Carvalho

Elisabeth J Van Bockstaele

Affiliations

Soon will be listed here.

Abstract

The cannabinoid system is known to interact with a variety of neuromodulators in the central nervous system and impacts diverse behaviors. Previous studies have demonstrated that limbic norepinephrine is a critical determinant in the behavioral expression of cannabinoid-induced aversion. The present study was carried out to define the adrenergic receptor subtype involved in mediating cannabinoid-induced behavioral responses. An acute microinjection of the β1-adrenergic receptor blocker, betaxolol, directly into the nucleus accumbens (Acb), was able to prevent WIN 55,212-2-induced aversion, but not lithium-induced aversion, as measured in a place conditioning paradigm. These results suggest that noradrenergic transmission in the Acb is important for cannabinoid-induced aversion and that beta-adrenergic antagonists may be effective in counteracting negative side effects of cannabinoid-based agents.

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