Radiation Metabolomics and Its Potential in Biodosimetry

Overview

Journal Int J Radiat Biol

Specialty Radiology

Date 2011 Jun 23

PMID 21692691

Citations 59

Authors

Stephen L Coy

Amrita K Cheema

John B Tyburski

Evagelia C Laiakis

Sean P Collins

Albert Fornace Jr

Affiliations

Soon will be listed here.

Abstract

Purpose: Radiation exposure triggers a complex network of molecular and cellular responses that impacts metabolic processes and alters the levels of metabolites. Such metabolites have potential as biomarkers for radiation dosimetry. This review provides an overview of radiation signalling and metabolism, of metabolomic approaches used in the discovery phase, and of instrumentation with the potential to assess radiation injury in the field.

Approach: Recent developments in fast, high-resolution chromatography and mass spectrometry and new data analysis methods allow the quantitative assessment of thousands of metabolites based on biofluids obtained non-invasively. This complex analysis leads to the discovery-phase identification of groups of metabolites useful for screening and biodosimetry by targeted quantitative measurement. Instrumentation for target analysis can be simpler than that used for discovery, so we examine current technologies based on ion mobility.

Conclusions: Recent published results and ongoing studies examine the complex changes in the levels of many metabolites caused by radiation exposure, and identify groups of small-molecule biomarkers for radiation biodosimetry. Based on results showing separation orthogonal to mass, chemical noise suppression, and high sensitivity, differential mobility mass spectrometry (DMS-MS) ion mobility spectrometry appears highly promising for the development of deployable instrumentation.

Citing Articles

Metabolomic Changes in Plasma of Preterminal Stage of Rhesus Nonhuman Primates Exposed to Lethal Dose of Radiation.

Carpenter A, Fatanmi O, Wise S, Petrus S, Tyburski J, Cheema A Metabolites. 2024; 14(1).

PMID: 38248821 PMC: 10819041. DOI: 10.3390/metabo14010018.

Paper-Based Vertical Flow Immunoassay for the Point-of-Care Multiplex Detection of Radiation Dosimetry Genes.

Lacombe J, Summers A, Khanishayan A, Khorsandian Y, Hacey I, Blackson W Cytogenet Genome Res. 2023; 163(3-4):178-186.

PMID: 37369178 PMC: 10751381. DOI: 10.1159/000531702.

Transcriptomes of Wet Skin Biopsies Predict Outcomes after Ionizing Radiation Exposure with Potential Dosimetric Applications in a Mouse Model.

Alkhalil A, Clifford J, Miller S, Gautam A, Jett M, Hammamieh R Curr Issues Mol Biol. 2022; 44(8):3711-3734.

PMID: 36005150 PMC: 9406351. DOI: 10.3390/cimb44080254.

Medical management of acute responses to radiation.

Chao N, Case C, Confer D Hemasphere. 2022; 3(Suppl).

PMID: 35309803 PMC: 8925706. DOI: 10.1097/HS9.0000000000000225.

Enhancement of Acylcarnitine Levels in Small Intestine of Abdominal Irradiation Rats Might Relate to Fatty Acid β-Oxidation Pathway Disequilibration.

Liu H, Lu X, Zhao H, Li S, Gao L, Tian M Dose Response. 2022; 20(1):15593258221075118.

PMID: 35221822 PMC: 8874182. DOI: 10.1177/15593258221075118.

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