Pediatric Temporal Low-grade Glial Tumors: Epilepsy Outcome Following Resection in 48 Children

Overview

Journal Childs Nerv Syst

Specialty Pediatrics

Date 2011 Jun 22

PMID 21691825

Citations 13

Authors

Shimrit Uliel-Sibony

Uri Kramer

Itzhak Fried

Aviva Fattal-Valevski

Shlomi Constantini

Affiliations

Soon will be listed here.

Abstract

Purpose: This paper summarizes our experience with surgical treatment of pediatric low-grade glial temporal lobe tumors focusing on the long-term outcome of seizures and identifying factors associated with seizure control and failure.

Methods: We reviewed all medical records of pediatric patients that underwent temporal lobe surgery due to seizures at our institution between 1997 and 2009. Only patients with temporal lobe tumors were included in this series. The files were retrospectively reviewed for seizure history. All children had undergone pre- and postoperative evaluation, neurological examination, EEG, and MRI.

Results: The cohort includes 48 children with mean follow-up time of 5.15 years (1-12 years). The mean age at surgery was 8.2 years (1-18.1) and the mean seizure duration until surgery was 2.6 years. All lesions in the cohort were low-grade tumors; pilocytic astrocytoma was the most common (41%). Eighty-three percent of the patients were classified as Engel class I following surgery. There was no correlation between Engel score and the preoperative epilepsy duration, age of seizure onset or type of seizures, and pathology. The surgical complication rate was 4.1% (2/48).

Conclusions: Surgical treatment for seizure control in children and adolescents with low-grade temporal tumors provides excellent long-term results.

Citing Articles

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Predictive factors for seizure freedom after epilepsy surgery for pediatric low-grade tumors and focal cortical dysplasia.

Hornak A, Bolton J, Tsuboyama M, Pearl P, Dam S, Moore T Epilepsy Behav Rep. 2024; 27:100680.

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The Pediatric Epilepsy Surgery Interest Group (PESIG) under the auspice of the ISPN Research Committee: Availability of relevant technology and geographical distribution.

Roth J, Weiner H, Chandra P, Machado H, Blount J, Dorfmuller G Childs Nerv Syst. 2023; 40(4):1239-1244.

PMID: 38032484 DOI: 10.1007/s00381-023-06236-0.

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