Progress in the Prospective Study of the Schizophrenia Prodrome

Overview

Journal Curr Psychos Ther Rep

Publisher Current Science

Specialty Psychiatry

Date 2011 Jun 22

PMID 21691454

Citations 1

Authors

Emery J Fu

Kristin S Cadenhead

Affiliations

Soon will be listed here.

Abstract

Further understanding of the schizophrenia spectrum has helped to define the prodrome of the illness, leading to hopes of earlier identification and intervention in susceptible, at-risk individuals. Given the heterogeneity and comorbidity observed in the clinically and demographically identified prodromal sample, it is essential that neurobiological markers that are more closely linked to brain function, and perhaps the ability to predict evolution of psychosis, be identified. Ultimately, it may be possible to identify an algorithm of risk factors that will combine clinical and demographic risk factors with vulnerability markers associated with later development of schizophrenia to better target at-risk individuals or preventative treatment.

Citing Articles

Understanding the schizophrenia prodrome.

George M, Maheshwari S, Chandran S, Manohar J, Rao T Indian J Psychiatry. 2018; 59(4):505-509.

PMID: 29497198 PMC: 5806335. DOI: 10.4103/psychiatry.IndianJPsychiatry_464_17.

References

Cantor-Graae E, Selten J . Schizophrenia and migration: a meta-analysis and review. Am J Psychiatry. 2004; 162(1):12-24. DOI: 10.1176/appi.ajp.162.1.12. View

Yung A, Phillips L, Yuen H, McGorry P . Risk factors for psychosis in an ultra high-risk group: psychopathology and clinical features. Schizophr Res. 2004; 67(2-3):131-42. DOI: 10.1016/S0920-9964(03)00192-0. View

Cadenhead K, Light G, Geyer M, McDowell J, Braff D . Neurobiological measures of schizotypal personality disorder: defining an inhibitory endophenotype?. Am J Psychiatry. 2002; 159(5):869-71. DOI: 10.1176/appi.ajp.159.5.869. View

Freedman R, Coon H, Myles-Worsley M, Orr-Urtreger A, Olincy A, Davis A . Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus. Proc Natl Acad Sci U S A. 1997; 94(2):587-92. PMC: 19557. DOI: 10.1073/pnas.94.2.587. View

Mednick S, Machon R, Huttunen M, Bonett D . Adult schizophrenia following prenatal exposure to an influenza epidemic. Arch Gen Psychiatry. 1988; 45(2):189-92. DOI: 10.1001/archpsyc.1988.01800260109013. View

Hawkins K, Addington J, Keefe R, Christensen B, Perkins D, Zipurksy R . Neuropsychological status of subjects at high risk for a first episode of psychosis. Schizophr Res. 2004; 67(2-3):115-22. DOI: 10.1016/j.schres.2003.08.007. View

Hawkins K, McGlashan T, Quinlan D, Miller T, Perkins D, Zipursky R . Factorial structure of the Scale of Prodromal Symptoms. Schizophr Res. 2004; 68(2-3):339-47. DOI: 10.1016/S0920-9964(03)00053-7. View

Cornblatt B, Erlenmeyer-Kimling L . Global attentional deviance as a marker of risk for schizophrenia: specificity and predictive validity. J Abnorm Psychol. 1985; 94(4):470-86. DOI: 10.1037//0021-843x.94.4.470. View

Judd L, McAdams L, Budnick B, Braff D . Sensory gating deficits in schizophrenia: new results. Am J Psychiatry. 1992; 149(4):488-93. DOI: 10.1176/ajp.149.4.488. View

10.

Cadenhead K, Light G, Shafer K, Braff D . P50 suppression in individuals at risk for schizophrenia: the convergence of clinical, familial, and vulnerability marker risk assessment. Biol Psychiatry. 2005; 57(12):1504-9. DOI: 10.1016/j.biopsych.2005.03.003. View

11.

Brockhaus-Dumke A, Tendolkar I, Pukrop R, Schultze-Lutter F, Klosterkotter J, Ruhrmann S . Impaired mismatch negativity generation in prodromal subjects and patients with schizophrenia. Schizophr Res. 2005; 73(2-3):297-310. DOI: 10.1016/j.schres.2004.05.016. View

12.

Wood S, Yucel M, Velakoulis D, Phillips L, Yung A, Brewer W . Hippocampal and anterior cingulate morphology in subjects at ultra-high-risk for psychosis: the role of family history of psychotic illness. Schizophr Res. 2005; 75(2-3):295-301. DOI: 10.1016/j.schres.2004.10.008. View

13.

Cannon M, Jones P, Murray R . Obstetric complications and schizophrenia: historical and meta-analytic review. Am J Psychiatry. 2002; 159(7):1080-92. DOI: 10.1176/appi.ajp.159.7.1080. View

14.

Myles-Worsley M, Coon H, Byerley W, Waldo M, Young D, Freedman R . Developmental and genetic influences on the P50 sensory gating phenotype. Biol Psychiatry. 1996; 39(4):289-95. DOI: 10.1016/0006-3223(95)00134-4. View

15.

Weiser M, Reichenberg A, Grotto I, Yasvitzky R, Rabinowitz J, Lubin G . Higher rates of cigarette smoking in male adolescents before the onset of schizophrenia: a historical-prospective cohort study. Am J Psychiatry. 2004; 161(7):1219-23. DOI: 10.1176/appi.ajp.161.7.1219. View

16.

Miller T, McGlashan T, Rosen J, Cadenhead K, Cannon T, Ventura J . Prodromal assessment with the structured interview for prodromal syndromes and the scale of prodromal symptoms: predictive validity, interrater reliability, and training to reliability. Schizophr Bull. 2004; 29(4):703-15. DOI: 10.1093/oxfordjournals.schbul.a007040. View

17.

Klosterkotter J, Hellmich M, Steinmeyer E, Schultze-Lutter F . Diagnosing schizophrenia in the initial prodromal phase. Arch Gen Psychiatry. 2001; 58(2):158-64. DOI: 10.1001/archpsyc.58.2.158. View

18.

Pantelis C, Velakoulis D, McGorry P, Wood S, Suckling J, Phillips L . Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison. Lancet. 2003; 361(9354):281-8. DOI: 10.1016/S0140-6736(03)12323-9. View

19.

Arseneault L, Cannon M, Witton J, Murray R . Causal association between cannabis and psychosis: examination of the evidence. Br J Psychiatry. 2004; 184:110-7. DOI: 10.1192/bjp.184.2.110. View

20.

Haroun N, Dunn L, Haroun A, Cadenhead K . Risk and protection in prodromal schizophrenia: ethical implications for clinical practice and future research. Schizophr Bull. 2005; 32(1):166-78. PMC: 2632176. DOI: 10.1093/schbul/sbj007. View