Therapeutic Immune Clearance of Rabies Virus from the CNS

Overview

Journal Future Virol

Specialty Microbiology

Date 2011 Jun 21

PMID 21686076

Citations 12

Authors

D Craig Hooper

Anirban Roy

Rhonda B Kean

Timothy W Phares

Darryll A Barkhouse

Affiliations

Soon will be listed here.

Abstract

The long-held concept that rabies infection is lethal in humans once the causative rabies virus has reached the CNS has been called into question by the recent survival of a number of patients with clinical rabies. Studies in animal models provide insight into why survival from a rabies virus infection that has spread to the CNS is possible and the immune mechanisms involved. In the CNS, both innate mechanisms capable of inhibiting virus replication and the activity of infiltrating rabies virus-specific T and B cells with the capacity to clear the virus are required. Deficiencies in the induction of either aspect of rabies immunity can lead to lethal consequences but may be overcome by novel approaches to active and passive immunization.

Citing Articles

Characterisation of a Live-Attenuated Rabies Virus Expressing a Secreted scFv for the Treatment of Rabies.

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Overcoming the blood-brain barrier for the therapy of malignant brain tumor: current status and prospects of drug delivery approaches.

Mitusova K, Peltek O, Karpov T, Muslimov A, Zyuzin M, Timin A J Nanobiotechnology. 2022; 20(1):412.

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Challenges of Rabies Serology: Defining Context of Interpretation.

Moore S Viruses. 2021; 13(8).

PMID: 34452381 PMC: 8402924. DOI: 10.3390/v13081516.

Brain tissue-resident immune memory cells are required for long-term protection against CNS infection with rabies virus.

Lebrun A, Kean R, Hooper D Future Virol. 2020; 15(11):755-761.

PMID: 33343683 PMC: 7737145. DOI: 10.2217/fvl-2020-0132.

Rabies virus vaccine as an immune adjuvant against cancers and glioblastoma: new studies may resurrect a neglected potential.

Altinoz M, Guloksuz S, Elmaci I Clin Transl Oncol. 2017; 19(7):785-792.

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