Glia Instruct Developmental Neuronal Remodeling Through TGF-β Signaling

Overview

Journal Nat Neurosci

Date 2011 Jun 21

PMID 21685919

Citations 83

Authors

Takeshi Awasaki

Yaling Huang

Michael B OConnor

Tzumin Lee

Affiliations

Soon will be listed here.

Abstract

We found that glia secrete myoglianin, a TGF-β ligand, to instruct developmental neural remodeling in Drosophila. Glial myoglianin upregulated neuronal expression of an ecdysone nuclear receptor that triggered neurite remodeling following the late-larval ecdysone peak. Thus glia orchestrate developmental neural remodeling not only by engulfment of unwanted neurites but also by enabling neuron remodeling.

Citing Articles

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