Use of Hypothermia to Allow Low-tidal-volume Ventilation in a Patient with ARDS

Overview

Journal Respir Care

Publisher Mary Ann Liebert

Specialty Pulmonary Medicine

Date 2011 Jun 21

PMID 21682985

Citations 10

Authors

Melissa Duan

Lorenzo Berra

Asheesh Kumar

Susan Wilcox

Steve Safford

Robert Goulet

Michelle Lander

Ulrich Schmidt

Affiliations

Soon will be listed here.

Abstract

Low-tidal-volume ventilation reduces mortality in patients with ARDS, but there are often challenges in implementing lung-protective ventilation, such as acidosis from hypercapnia. In a patient with severe ARDS we achieved adequate ventilation with a very low tidal volume (4 mL/kg ideal body weight) by inducing mild hypothermia (body temperature 35-36°C).

Citing Articles

Design and rationale of the CHILL phase II trial of hypothermia and neuromuscular blockade for acute respiratory distress syndrome.

Shanholtz C, Terrin M, Harrington T, Chan C, Warren W, Walter R Contemp Clin Trials Commun. 2023; 33:101155.

PMID: 37228902 PMC: 10191700. DOI: 10.1016/j.conctc.2023.101155.

Severe Hypercapnia Requiring 48-h Whole-Body Hypothermia in an Infant with Acute Bronchiolitis.

Librandi M, Scapaticci S, Chiavaroli V, Petrucci A, Cicioni P, Cognigni R Children (Basel). 2022; 9(9).

PMID: 36138647 PMC: 9498189. DOI: 10.3390/children9091339.

Strategies to protect surfactant and enhance its activity.

De Luca D, Autilio C Biomed J. 2021; 44(6):654-662.

PMID: 34365021 PMC: 8847817. DOI: 10.1016/j.bj.2021.07.011.

Hypermetabolism in critically ill patients with COVID-19 and the effects of hypothermia: A case series.

Yu P, Cassiere H, Bocchieri K, DeRosa S, Yar S, Hartman A Metabol Open. 2020; 7:100046.

PMID: 32808941 PMC: 7382710. DOI: 10.1016/j.metop.2020.100046.

Expression profiling of microRNAs in lipopolysaccharide-induced acute lung injury after hypothermia treatment.

Lee W, Kim I, Shin S, Park K, Yang K, Eun J Mol Cell Toxicol. 2020; 12(3):243-253.

PMID: 32226458 PMC: 7096978. DOI: 10.1007/s13273-016-0029-7.